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Gastroretentive Delivery Systems are employed to improve the bioavailability of drugs which are absorbed through upper part of GIT, by increasing their retention time. Incorporation of permeability enhancers in the for...

Las semillas de Cucurbita pepo L., por su elevado porcentaje de aceite fijo, son ricas en ácidos grasos poliinsaturados, fitoesteroles, tocoferoles y carotenoides, empleándose tradicionalmente como antiinflamatorio en ...

Las microemulsiones son mezclas isotrópicas, estables, claras, constituidas por una fase oleosa, una acuosa y uno o más anfifílicos. Despiertan interés a nivel farmacéutico debido a varias ventajas que ofrecen: ca...

A micellar liquid chromatographic method was developed for the simultaneous analysis of a binary mixture of norfloxacin and tinidazole (NOR and TIN) in dosage forms and human plasma. The analysis was carried out using a ...

A instilação tópica de colírios no saco conjuntival inferior é o procedimento mais correntemente empregado para a administração de fármacos oftálmicos. Entretanto, um dos maiores problemas encontrados com a admi...

O tratamento farmacológico de patologias oculares é conduzido pelas vias de administração sistêmica e local. A via sistêmica apresenta limitações relacionadas à concentração do princípio ativo nos tecidos o...

A tuberculose é uma doença negligenciada causada pelo Mycobacterium tuberculosis. São estimados dois milhões de óbitos e oito milhões de novos casos por ano, sendo 490.000 casos multi-droga resistentes. Fármacos...

Niosomes have been reported as a possible approach to improve the low skin penetration and bioavailability characteristics shown by conventional topical vehicle for Baclofen (centrally acting skeletal muscle relaxant)....

The present study utilizes approach of solid dispersions (SDs) to improve dissolution rate of Gliclazide (GLZ); a poorly water soluble anti-diabetic drug. Formulations were prepared by solvent evaporation and melt disper...

Los objetivos del presente trabajo fueron comparar la penetración in líquido tisular de músculo (MTF) y tejido muscular (MT) de cefalotina administrada a conejos. Los animales fueron distribuidos en Experimento 1 (n =...

The objective of the work was to develop, optimize and evaluate self-microemulsifying drug delivery system (SMEDDS) of carvedilol (CDL), a poorly water-soluble drug. SMEDDS was developed to increase the solubility, disso...

4'-ethyl-7-phenylsulfonylgenistein (EPG, 3), a potential prodrug for genistein (1), was synthesized in high yield and its crystal structure was reported firstly. It possesses better physical and chemical properties such ...

Después de una breve introducción referida a la presencia de principios activos naturales con acción alucinógena, se presenta una reseña histórica concerniente al uso de la "iboga" en ceremonias rituales del culto ...

En este trabajo se hace una revisión de los sistemas matriciales en lo que concierne a su formulación, concepción, diseño y sus propiedades biofarmacéuticas. Estos sistemas se caracterizan por retardar y regular l...

The antibiotic cefuroxime axetil is extremely bitter. The present study deals with development of taste-masked resinates of cefuroxime axetil using ion exchange resins. The drug resin complexation procedure was optimized...

The aim of the study was to characterize the preclinical pharmacokinetics and comparative pharmacokinetics of pure vitexin-2"-O-rhamnoside (VR) in mice after oral and intravenous administration at dose of 30 mg/kg. A sen...