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BackgroundCongenital athymia (CA) is a rare T cell immune deficiency, fatal without curative treatment with allogeneic processed thymus tissue–agdc (RETHYMIC) implantation (here termed CTTI). The rate and extent of T c...

We previously reported that inherited human retinoic acid-related orphan receptor gamma T (RORγT) deficiency underlies mycobacterial disease and chronic mucocutaneous candidiasis (CMC) in seven patients from three ances...

Thyroid hormones play a key role in adipose tissue development and function. Hypothyroidism (HypoT) can delay mammary tumor development in rats, possibly by altering mammary adipose tissue (MAT) and its interaction with ...

IntroductionLow T cell receptor excision circles (TRECs) on newborn screen and severe T cell lymphopenia in a term newborn raise concern for severe combined immunodeficiency (SCID). Genetic polymorphisms in thiopurine me...

O músculo estriado esquelético é formado pela associação de fibras musculares com a matriz extracelular. Esse tecido possui alta plasticidade e o conhecimento das características morfológicas, da miogênese, e da ...

Abstract Transcriptomics enables comprehensive, multiplexed characterization of cellular states, yet prevailing methods typically require cell fixation or lysis, precluding longitudinal analysis of RNA expression in livi...

BackgroundExpression levels of transmembrane protein 41A (TMEM41A) are related to the progression of malignant tumors. However, the association between TMEM41A expression and endometrial carcinoma (EC) remains unclear. T...

IntroductionThe precise mechanisms linking TCR-dependent nutrient import and metabolic reprogramming to CD4+ T helper (Th) fate and function remain elusive. Here, we show that the CARD11–BCL10–MALT1 (CBM) complex fac...

Abstract Targeting the BCL-2 family of proteins, key regulators of cellular apoptosis, with BH3-mimetics has been a major therapeutic goal to overcome cancer cell death resistance. However, beyond their canonical roles i...

Background: Cancer stem cells are important for the development of many solid tumors. These cells receive promoting and inhibitory signals that depend on the nature of their environment (their niche) and determine cell d...

Objetivos: os autores modificaram a espátula de Ayre original visando otimizar a colheita endocervical. O estudo verificou se a capacidade da espátula modificada em colher células da endocérvice é semelhante à obti...

Conventional approaches for the detection of antibody dependent cell-mediated cytotoxicity (ADCC) activity rely on quantification of the release of traceable compounds from target cells or flow cytometry analysis of popu...

γδ T cells in human solid tumors remain poorly defined. Here, we describe molecular and functional analyses of T-cell receptors (TCRs) from tumor-infiltrating γδ T lymphocytes (γδ TILs) that were in direct contact ...

Las células enteroendócrinas (CEE) del intestino son células relacionadas con la motilidad, secreción y absorción de nutrientes. Su rol relacionado a la función inmunológica está siendo estudiado recientemente. E...

Se realizó el estudio anatómico comparativo de dos especies de la familia Loranthaceae provenientes de la provincia de Jujuy: Ligaria cuneifolia (R. et P.) Tiegh.var. cuneifolia (R.et P.) Blume y Tristerix verticillatu...

Tesis de Doctorado Las células folículo-estrelladas (CFE) son una población celular no-endocrina de la adenohipófisis, caracterizada por su fenotipo estrellado y largas prolongaciones citoplasmáticas que forman una ...

Fil: Cardozo, Alejandra Johana. Hospital Italiano; Argentina. Como el sistema nervioso tiene una capacidad limitada de autorreparación, y la neurogénesis en el adulto está restringida a ciertas regiones del cerebro, ...

El objetivo de este trabajo fue analizar la respuesta inmune mediada por células en la infección por Neospora caninum a través de la utilización de un modelo in vitro. Se obtuvieron células esplénicas de bovinos se...

During the larval period of Bufo arenmum, the horny teeth of the oral apparatus are developed from column of cells. Each column of cells is composed of a few number of epithelial cells catefully arranged and placed perpe...

Tesis de Licenciatura Las células madre mesenquimales son células madre adultas que pueden originar principalmente derivados de la línea mesodérmica, como osteocitos, adipocitos y condrocitos. En numerosas especies, ...

The off-label use of imiquimod (IQ) for hemangioma treatment has shown clinical benefits. We have previously reported a selective di- rect IQ-cytotoxic effect on transformed H5V endothelial cells (EC) (hemangioma model) ...

El cáncer de próstata (CaP) es el segundo tipo de cáncer másfrecuentemente diagnosticado en hombres. En estadíos avanzados laenfermedad puede diseminarse siendo el hueso el principal sitio de metástasis.Este no es ...

Fil: Fernández, Esteban Rodrigo. Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos Malbrán". Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben"; Argentina. La enfermedad de Chagas, ...

Infiltrating stromal and immune cells form the major fraction of normal cells in tumour tissue and not only perturb the tumour signal in molecular studies but also have an important role in cancer biology. Here we descri...