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The aim of the present investigation is to improve the dissolution of poorly water soluble drug valsartan by preparing solid dispersions and also to evaluate the effect of different inert carriers on flow properties of s...

En el presente trabajo se estudió la influencia de la granulometría del diluyente-aglutinante (Avicel PH 101 o Avicel PH 102) y el tipo de lubricante (estearato de magnesio o ácido esteárico), mediante un diseño fac...

El herbicida atrazina es uno de los principales plaguicidas aplicados de manera intensiva a nivel mundial. El objetivo del presente trabajo fue evaluar el efecto de atrazina sobre la reproducción y su control endocrino ...

Several colorimetric and chromatographic methods have been used for the identification and quantification of methyldopa (MA) in pharmaceutical formulations and clinical samples. However, these methods are time- and reage...

To select the suitable concentration level of controlled release polymer for the formulation of predefined extended release formulation based on the solubility behaviour of active substance, we have formulated and evalua...

Gastroretentive Delivery Systems are employed to improve the bioavailability of drugs which are absorbed through upper part of GIT, by increasing their retention time. Incorporation of permeability enhancers in the for...

In the present investigation, extended release tablets of metoprolol succinate were developed using cellulose derivatives and natural gums as matrix formers and were evaluated for its extended release characteristics. Th...

El efecto de una formulación líquido cristalina en la actividad antioxidante in vitro de la quercetina fue investigada utilizando diferentes metodologías con objetivo de escoger el método más adecuado para hacer el ...

The purpose of this work is to explore the potential of combining poloxamer 407 and carrageenan for its utilization in an injectable depot drug release system. Reverse thermal gelation of these formulations allow the loc...

Synthesis of new drugs, their rational design, or isolation from natural sources has decreased, and these facts lead to the use of currently marketed drugs. Some of them, extensively used, show unfavorable properties rel...

The aims of this work are obtaining and evaluating paracetamol oral suspension 32 mg/mL by qualitative and quantitative planning of the ingredients. The observations of the physical-chemical formulations were based in co...

Se evaluó el comportamiento de diferentes polímeros de derivados celulósicos y vinílicos utili- zados en la elaboración de comprimidos de ácido acetilsalicílico (AAS) formulados como matríz hidrofilica. Se realiz...

Microspheres were prepared using the emulsion/solvent evaporation method with the aim of obtaining diclofenac sodium (DFS) prolonged release dosage forms. The effects of the drug:polymer ratio and addition of Pluronic F6...

The objective of the work was to develop, optimize and evaluate self-microemulsifying drug delivery system (SMEDDS) of carvedilol (CDL), a poorly water-soluble drug. SMEDDS was developed to increase the solubility, disso...

Un acabado conocimiento del proceso de toma de decisiones y de los actores que intervienen en la formulación de la política exterior, resulta indispensable para cualquier intento de relación con un país. Este es el o...

Choline citrate (CC) and acetylmethionine (AM) are lipotropic drugs used in several pharmaceutical formulations. The objective of this research was to develop and validate a high performance liquid chromatographic (HPLC...

Formulation and in vitro evaluation of losartan potassium (LP) loaded transdermal delivery system (TDS) was investigated for controlled release and improved therapeutic efficacy. TDS (patches) were prepared by varying th...

The present study was undertaken to investigate the effect of nature of polymers like HPMC, carbopol-934P and their content levels on the release profiles of water soluble drug, diclofenac potassium. For this purpose, di...

Fast release capsules, containing sertraline hydrochloride, pregelatinized maize starch and microcrystalline cellulose were formulated. For this purpose, different technological assays were elaborated being the formula...

As formulações fitoterápicas contendo Passiflora alata (maracujá), Erythrina mulungu (mulungu), Leptolobium elegans (perobinha do campo) e Adonis vernalis (adonis) Ritmoneuran Solução® e Ritmoneuran Cápsulas® fo...

Professor Arnold Kaufmann did propose at least two types of indexes for estimating fuzziness in finite standard fuzzy sets. First one has an analogue formulation to that stated by Claude Shannon for measuring uncertainty...

Los análogos de la hormona liberadora de gonadotrofinas (GnRH), que incluyen agonistas y antagonistas, se sintetizaron por la sustitución de aminoácidos en la molécula original con el fin de obtener mayor potencia, d...

The network structure of a hyperlinked environment can be a rich source of information about the content of the environment, provided we have effective means for understanding it. We develop a set of algorithmic tools fo...

One of the problems which has plagued those attempting to predict the behavior of capital markets is the absence of a body of positive microeconomic theory dealing with conditions of risk. Although many useful insights c...