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Abstract Chimeric antigen receptor macrophage (CAR-M) therapy has emerged as a highly promising novel platform in solid tumor immunotherapy. Leveraging its inherent tumor-homing capacity, potent phagocytic function, and ...

Abstract Generative deep learning models have demonstrated significant potential in designing drug-like molecules. However, medicinal chemistry typically requires generating analogues that combine structural similarity w...

Abstract Tuberculosis (TB) has high morbidity and mortality rates, and drug-resistant strains pose an increasing challenge. Traditional methods for detecting the Mycobacterium tuberculosis complex (MTBC) are insufficient...

Abstract Background Leishmaniasis is a vector-borne disease caused by a protozoan parasite of the genus Leishmania. The infection is transmitted by the bite of infected female sandflies of the genus Phlebotomus in the Ol...

Abstract Background Induced mutation through physical mutagens, such as gamma irradiation is an effective and complementary breeding tool to enhance crop improvement by increasing genetic variation and creating heritable...

Abstract Background Preeclampsia (PE) is a major cause of maternal and fetal mortality andmorbidity. Its etiology is idiopathic, but it is known that the disease is associated with a prothrombotic state. In this context,...

Abstract Background Comprehensive genomic analysis and optimal treatment for non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) G719X + S768I co-mutations remain limited. This st...