NODOVOX | Discovery

DNA methylation signatures of Life’s Essential 8 and their implications for dementia

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DNA methylation signatures of Life’s Essential 8 and their implications for dementia

David Lukacsovich et al · BMC · 2025 · ISSN 1758-9193

Abstract Background As dementia cases continue to rise, effective prevention strategies are urgently needed. However, objective biomarkers that directly reflect lifestyle factors remain limited. Life’s Essential 8 (LE8...

LCC LCC:Neurosciences. Biological psychiatry. Neuropsychiatry; LCC:Neurology. Diseases of the nervous systemIdioma eng

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Inflammatory signaling differentially changes chromatin accessibility and gene expression of the PD- associated kinase LRRK2 between human and mice

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Inflammatory signaling differentially changes chromatin accessibility and gene expression of the PD- associated kinase LRRK2 between human and mice

Alexandra Beilina et al · BMC · 2026 · ISSN 1750-1326

Abstract The genomic locus that encodes the Leucine-rich repeat kinase 2 (LRRK2) gene is highly pleiotropic and associated with Parkinson’s disease (PD). Coding variants associated with risk of PD act as gain of functi...

LCC LCC:Neurology. Diseases of the nervous system; TENDOkdlcmlhdHJpY3M~Idioma eng

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Prevention and postvention guidance relating to self-harm and suicide for UK educational and youth organisations: a systematic review of grey literature

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Prevention and postvention guidance relating to self-harm and suicide for UK educational and youth organisations: a systematic review of grey literature

Emily Widnall et al · BMC · 2026 · ISSN 1471-2458

Abstract Introduction Self-harm and suicide among young people are major public health concerns and delivering prevention and postvention support is crucial. Educational and youth organisations play a vital role in both ...

LCC LCC:Public aspects of medicineIdioma eng

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The contribution of environmental DNA to exploring hypogeous fungal diversity and vulnerability

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The contribution of environmental DNA to exploring hypogeous fungal diversity and vulnerability

Chang Wan Seo et al · BMC · 2026 · ISSN 1471-2180

Abstract Background Hypogeous fungi play important ecological roles and have significant economic value. However, the hypogeous habit of these organisms hinders our understanding of their diversity and vulnerability. Res...

LCC TENDOk1pY3JvYmlvbG9neQ~~Idioma eng

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[18F]FDG PET/CT multiomics identifies Hedgehog-driven HPV-negative head and neck squamous cell carcinoma

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[18F]FDG PET/CT multiomics identifies Hedgehog-driven HPV-negative head and neck squamous cell carcinoma

Stefan Stoiber et al · BMC · 2026 · ISSN 1476-4598

Abstract Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous malignancy with limited predictive markers to guide personalized treatment, particularly in human papillomavirus (HPV)-negative cases, whic...

LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng

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