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Abstract Background Variants in OTUD5 are associated with neurodevelopmental disorders (NDDs), yet the underlying molecular mechanisms remain unclear. This study aimed to investigate the pathogenicity of a novel OTUD5 va...

Abstract Background Lung squamous cell carcinoma (LUSC) is one of the common pathological subtypes of non-small cell lung cancer, which poses significant treatment challenges due to poor response to conventional therapie...

Abstract Background High-oleic diets (HODs), have been proposed to improve lipid and glucose metabolism, yet clinical evidence remains inconsistent. This systematic review and meta-analysis aimed to quantitatively evalua...

Abstract Chenopodioideae plants are dominant components of desert ecosystems in arid regions of China and Central Asia and play key roles in maintaining ecosystem stability, while also providing valuable systems for unde...

Abstract Background Circadian rhythms are endogenous, transcription-translation feedback loops that align cellular activities with the 24-h light–dark cycle. Stem-cell populations across tissues exhibit circadian oscil...

Abstract Background Aging alters the systemic steroid environment, including reductions in circulating androgens. In peripheral tissues, androgen exposure is regulated mainly by local steroid metabolism, which can activa...

Abstract Background Hypoxia is a critical factor contributing to neuronal injury, primarily through dysregulation of hypoxia-inducible factor-1 alpha (HIF-1α). This study aimed to investigate the neuroprotective effects...

Abstract Background The Na⁺/H⁺ antiporter (NHX) family plays a crucial role in regulating intracellular Na and H homeostasis in plants. This study conducted a genome-wide analysis and expression assessment of peanut ...

Abstract Background Carotid atherosclerosis is a kind of systemic atherosclerosis in the carotid arteries. It remains one of the leading causes of ischemic stroke. However, the efficiency of treatment is insufficient. Th...

Abstract Intervertebral disc (IVD) degenerative disease is a prevalent and debilitating spinal disease. Current treatments only focus on symptomatic relief but fail to halt disease progression or restore the native biome...

Abstract Soil salinity poses a major constraint and a primary threat to global food security, demanding sustainable strategies to maintain crop productivity on marginal lands. This study evaluated the role of exogenous m...

Abstract Metabolic dysfunction associated fatty liver disease (MAFLD) is a rapidly growing global health burden characterized by hepatic lipid accumulation, insulin resistance, oxidative stress, and inflammation. Phyllan...

Abstract The emergence of ciprofloxacin-resistant Salmonella poses a significant challenge to antimicrobial therapy. Probiotics that inhibit ciprofloxacin-resistant Salmonella offer a safer alternative with fewer side ef...

Abstract Deoxynivalenol (DON), a prevalent Fusarium mycotoxin, poses a significant threat to intestinal health in piglets. This study established a deoxynivalenol (DON) intoxication model in piglets, revealing compromise...

Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic condition characterized by hepatic fat accumulation and systemic metabolic dysfunction. MASLD exhibits clear sex differenc...

Abstract Background In intensive livestock production, various environmental and management stressors often compromise the oxidative and immune homeostasis of lambs, thereby impairing their growth performance and health....

Abstract Selenoproteins incorporate the rare selenium-containing amino acid selenocysteine (Sec) and play crucial roles for redox homeostasis, stress response, and hormone regulation. Sec is inserted by co-translational ...