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Abstract Background Adverse events across the lifespan have been linked to poorer health outcomes, but the biological mechanisms remain unclear. The aim of this study was to quantify the independent and joint association...

Abstract Objectives DNA methylation (DNAm) can change dynamically in response to intrinsic or external exposures. Characteristic methylation profiles are associated with accelerated biological ageing and poorer health ou...

Abstract Background Ageism among healthcare professionals can undermine the quality of care for older adults, particularly those with high support needs in long-term care. Undergraduate dental curricula often provide lim...

Abstract Background Population ageing presents increasing challenges for health systems. Identifying complex needs and planning individualized care through Comprehensive Geriatric Assessment (CGA), promoting intergenerat...

Abstract Background Circadian rhythms are endogenous, transcription-translation feedback loops that align cellular activities with the 24-h light–dark cycle. Stem-cell populations across tissues exhibit circadian oscil...

Abstract Background Heart failure with preserved ejection fraction (HFpEF) disproportionately affects elderly women and is closely associated with central obesity and metabolic dysfunction. Although sodium-glucose co-tra...

Abstract Background Sarcopenia, altered bone and systemic metabolism, physical frailty and cognitive decline are age-dependent and interrelated phenomena. Sleep disorders which are erroneously considered as part of the a...

Abstract Background Migration can occur at any age and has long-term repercussions on health and well-being later in life. This study aims to assess cognitive functioning ability in later life and its association with ag...

Abstract Background Multiple inflammatory markers are central determinants of insulin resistance and cardiovascular inflammation, closely associated with cardiometabolic multimorbidity (CMM). However, the evidence regard...

Abstract Introduction Quality of life (QoL) is a core aspect of healthy ageing, reflecting the ability of older persons to adapt and maintain well-being in later life. Urban–rural differences pose distinct challenges, ...

Abstract Background Despite antiretroviral therapy (ART), people with HIV (PWH) face immunological ageing and accelerated comorbidities including coronary artery disease (CAD). Gut mucosal damage, chronic inflammation, a...

Abstract Background The ageing and growing population, rising cancer rate, and increased healthcare demand drive higher medical costs. Integrating Artificial Intelligence (AI) into oncology revolutionizes cancer diagnosi...

Abstract Introduction The ageing of the population is expected to increase the costs and consumption of health care. Care should be patient-centred. Patient-centred care (PCC) has been shown to increase the quality of li...