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Abstract Background Xenomonitoring is an approach of epidemiological infection risk assessment addressing vector-transmitted infections like malaria in hematophagous arthropods. Standardization and automation can facilit...

Abstract Background Non-invasive prenatal testing (NIPT) is a genetic test to screen fetal chromosomal abnormalities in pregnancy. Public reliance on short-video platforms for health information in China is increasing, y...

Abstract Background Health assessment instruments are essential for individual health monitoring, yet most existing tools rely on periodic surveys and lack the capacity to integrate large-scale digital health data. With ...

Abstract Background Non-invasive prenatal testing (NIPT) has emerged as a highly accurate screening modality for fetal aneuploidies. However, its cost-effectiveness in resource-constrained settings remains unclear. This ...

Abstract Background Under pressures of health insurance cost containment and high-quality development, diagnosis-related groups (DRGs) and other case-based payment schemes have become a major direction of China’s inpat...

Abstract Background Contemporary orthodontic practice faces challenges related to treatment complications, often linked to deficiencies in multidisciplinary clinical competency. A clear understanding of the coordination ...

Abstract Background Postpartum depression and anxiety are common and burdensome. Physical activity (PA) is a scalable intervention, yet the comparative effectiveness of PA modalities and optimal dosing in the postpartum ...

Abstract Background Acute liver failure (ALF) is a life-threatening syndrome characterized by rapid deterioration of liver function, resulting in high mortality and posing a substantial global health burden. Human embryo...

Abstract High-throughput omics technologies have transformed our understanding of female reproductive biology, revealing molecular interactions governing oocyte maturation, ovarian reserve, endometrial receptivity, and e...

Abstract Objective To investigate whether serum lysyl oxidase-like 2 (LOXL2) and chitinase-3-like protein 1 (YKL-40) levels are associated with drug-resistant Mycobacterium tuberculosis in children with pulmonary tubercu...

Abstract Background Current understanding of the fluid biomarker profile in early-onset Alzheimer’s disease (EOAD) associated with pathogenic APP variants remains limited. We characterized four EOAD pedigrees carrying ...

Abstract Seed selection constitutes the initial and one of the most critical steps in agricultural productivity. The identification of high-quality seeds is a labor-intensive and costly process that requires considerable...

Abstract Background Nanosilver fluoride (NSF) has emerged as a promising alternative to silver diamine fluoride (SDF), addressing its major drawback of tooth discoloration. Incorporating silver nanoparticles, NSF retains...

Abstract Background The prevalence and spectrum of PALB2 pathogenic/likely pathogenic variants (PV/LPVs) may vary across different regions, and these have not yet been analysed and reported in Slovenian HBOC families. Me...

Abstract Background Neuronal intranuclear inclusion disease (NIID) is a rare and progressive neurodegenerative disorder, distinguished by extreme clinical heterogeneity that frequently results in diagnostic delays. Whil...

Abstract Objective The relationship between muscle function recovery and biomechanical alterations after anterior cruciate ligament reconstruction (ACLR) during high-risk movements remains unclear. This study aimed to in...

Abstract Background Bipolar disorder (BD) typically emerges during adolescence and is associated with substantial functional impairment, but objective physiological markers are scarce. The niacin skin flushing response (...

Abstract Background The World Health Organisation’s “Test, Treat, and Track” initiative for malaria underscores the need for accurate diagnosis to guide effective treatment and reduce drug misuse. In Ghana, about 7...

Abstract Background Drug-induced liver injury (DILI) remains a significant barrier to the safe and efficient use of antimalarial medicines. Many promising compounds fail in late-stage development or post-marketing owing ...