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Abstract Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisystem disease characterized by heterogeneous symptom patterns. Previous work suggested that specific symptoms tend t...

Abstract Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS) characterized by multifocal inflammation and axonal degeneration, driven by innate and adaptive immune cells. Th...

Abstract Objectives To analyze spatiotemporal clustering patterns of severe hand foot and mouth disease (HFMD) in children aged ≤ 5 years, quantify the associations between meteorological factors and severe HFMD in...

Abstract Background Mosquito movement is ubiquitous and complicates the design of cluster randomized trials (CRTs) of vector control interventions because it can cause spillover between trial arms. There has been no anal...

Abstract Background In China, the informed consent for thrombolysis in patients with AIS tends to be primarily signed by proxy decision-makers, generally for the family members of patients. The decision-making process is...

Abstract Background Entomological outcomes are critical for understanding the biological mechanisms and operational performance of malaria vector control interventions. However, the quality and consistency of how these o...

Abstract Objective Streptococcus shenyangsis is a recently reported member of the genus Streptococcus, rarely detected in the human oral cavity and for which genomic information remains limited. To broaden our understand...

Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease characterized by aberrant immune responses and tissue remodeling. Ligustrazine has multiple effects, such as enh...

Abstract Background Melissa officinalis (balm) is a perennial medicinal. Climate change and high cultivation costs necessitate the breeding of new cultivars with improved stress tolerance and high metabolite content. How...

Abstract Background Klebsiella pneumoniae complex (Kp) is a relevant neonatal pathogen colonizing preterm infants. While outbreak investigations often focus on multidrug-resistant strains, the epidemiology and genomic dy...

Abstract Background In Libreville, Gabon, the Melen sentinel site has monitored malaria among febrile children for over a decade, offering a lens on intra-urban transmission. We aimed to characterize neighborhood-level s...

Abstract Aims This study aims to analyze the clustering characteristics of health risk behaviors in adolescents with depression, and explore the mechanism of psychological resilience and depression in childhood abuse and...