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Abstract Objectives Gastroesophageal reflux disease (GERD) is estimated to affect up to one-quarter of the Italian population, generating immense treatment costs. An emergent surgical treatment involving implantation of ...

Abstract Background Non-invasive prenatal testing (NIPT) has emerged as a highly accurate screening modality for fetal aneuploidies. However, its cost-effectiveness in resource-constrained settings remains unclear. This ...

Abstract Objective To evaluate the cost-effectiveness of zanubrutinib compared to ibrutinib in the first-line treatment of chronic lymphocytic leukemia (CLL) / small lymphocytic lymphoma (SLL) from the perspective of the...

Abstract Background Racial and ethnic minorities and those with lower incomes are disproportionately affected by chronic kidney disease (CKD). The objectives of this study were to estimate the prevalence of access barrie...

Abstract Background Semaglutide, a glucagon-like peptide-1 receptor agonist, and resmetirom, a thyroid hormone receptor-β agonist, are approved therapies for noncirrhotic metabolic dysfunction–associated steatohepatit...

Abstract Background Obesity is a significant contributor to global morbidity and mortality, driven by rising consumption of unhealthy energy dense foods high in salt, sugar and fat (HFSS). Supermarkets, pivotal in food d...

Abstract Background Adoptive cell therapy with tumour-infiltrating lymphocytes has been recognised as a safe and effective treatment for patients with advanced melanoma. Whether such a novel intervention is cost-effectiv...

Abstract Background The ageing and growing population, rising cancer rate, and increased healthcare demand drive higher medical costs. Integrating Artificial Intelligence (AI) into oncology revolutionizes cancer diagnosi...

Abstract Background Although trimodal prehabilitation programs have demonstrated clinical benefits in oncologic surgery, evidence regarding their financial sustainability in public health systems of middle-income countri...