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Abstract Background Health assessment instruments are essential for individual health monitoring, yet most existing tools rely on periodic surveys and lack the capacity to integrate large-scale digital health data. With ...

Abstract Background Hypertension is an important risk factor for cardiovascular diseases, morbidity and mortality. In Germany, elevated systolic blood pressure is associated with more than half of all cardiovascular deat...

Abstract Background Accurate and timely estimation of nitrogen nutrition index (NNI) is critical for assessing crop nitrogen (N) status and implementing precision N management. While machine learning (ML) techniques comb...

Abstract Background Our objective is to investigate the association between prospectively-reported and retrospectively-reported falls data and the likelihood of subsequent falls in a cohort of patients with and without v...

Abstract Background The reuse of health data is critical for advancing health research, yet it raises complex ethical, legal, and societal challenges. In the European Union, the recently adopted European Health Data Spac...

Abstract Background Iron overload promotes atherosclerosis in mice and causes vascular dysfunction in humans with Hemochromatosis. However, data are controversial on whether systemic iron availability within physiologica...

Abstract The Internet of Healthcare Things (IoHT) is an emerging technology that has attracted researchers’ interest due to its broad applicability in recent years. In IoHT platforms, sensors continually collect patien...

Abstract Background Adaptive designs (ADs) are increasingly used, whereby outcome data accumulated during the trial may inform a trial’s course in accordance with pre-specified rules at interim analyses. The benefits h...