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Abstract Background Alzheimer’s disease (AD) is a growing global health concern, and emerging evidence suggests that oral health—particularly tooth loss—may be linked to cognitive decline. While implant therapy eff...

Abstract Background Bright Light Therapy is effective in improving sleep and circadian rhythms. However, little is known regarding the effects of BioDynamic Lighting. The current study examined whether BioDynamic Lightin...

Abstract Background As dementia cases continue to rise, effective prevention strategies are urgently needed. However, objective biomarkers that directly reflect lifestyle factors remain limited. Life’s Essential 8 (LE8...

Abstract Background Enhanced Group Activity Kits (EGAKs) were developed to maximize the impact of group activities for persons living with dementia while minimizing burden on activity leaders. Previous research has shown...

Abstract Background Older people with dementia are regularly excluded from decision-making processes and their wishes and preferences for care are often not respected. The aim of this study was to analyze whether the use...

Abstract Background Neuropsychiatric symptoms (NPS) are highly prevalent in nursing home residents. The main aims of this study were to examine whether music-based care (MBC) had sustained effects on NPS in nursing home ...

Abstract Background Primary care is increasingly tasked with early detection, diagnosis, and management of dementia. Despite policy initiatives, education investments, and development of diagnostic and care pathways in A...

Abstract Background This study evaluates the impact of the SOCAV program on promoting self-direction of individuals with dementia in nursing homes and examines the behavioral changes in care staff when trained and coache...

Abstract Accumulation of amyloid beta 1–42 (Aβ42) peptide in the extracellular space in the brain is a major observation in Alzheimer’s Disease (AD)-related pathology. Astrocytes are known to play pivotal role in cl...

Abstract Background Sarcopenia, the age-related loss of muscle mass and strength, is a leading cause of disability and frailty in older adults. Though primarily seen as a musculoskeletal condition, emerging evidence sugg...

Abstract Background Intertrochanteric femoral fractures are common in the elderly population and are associated with substantial mortality. While fracture reduction quality is known to influence mechanical outcomes, its ...

Abstract Background Subjective cognitive decline and mild cognitive impairment represent critical windows for intervention as early stages of dementia progression. Although digital health interventions have shown potenti...

Abstract Background Mild cognitive impairment (MCI) is an intermediate stage between normal cognitive aging and dementia. People with MCI have a higher risk of developing dementia than normal healthy people. Improving th...

Abstract Background Insomnia, which is a common complaint among older adults, is associated with cognitive deterioration and a lower quality of life. Kami Guibi-tang (KGT), traditional Eastern herbal medicine, is known t...

Abstract Background Recruitment and retention remain persistent challenges in Alzheimer’s disease (AD) clinical trials, particularly as studies increasingly focus on earlier disease stages and require longer participat...

Abstract Introduction Quality of life (QoL) is a core aspect of healthy ageing, reflecting the ability of older persons to adapt and maintain well-being in later life. Urban–rural differences pose distinct challenges, ...

Abstract Mutations in the presenilin (PS/PSEN) genes cause early-onset familial Alzheimer’s disease (AD) by enhancing cerebral accumulation of amyloid-β (Aβ) peptides and microtubule-associated protein tau (MAPT). Ho...

Abstract Background ADAM10 and ADAM17, members of the membrane-bound disintegrin metalloproteinase (ADAM) family, act as α-secretases in the non-amyloidogenic processing of the amyloid precursor protein. While alteratio...

Abstract Background Sarcopenia, altered bone and systemic metabolism, physical frailty and cognitive decline are age-dependent and interrelated phenomena. Sleep disorders which are erroneously considered as part of the a...