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Abstract Background Plasma glial fibrillary acidic protein (GFAP) has emerged as a promising biomarker of astrocytic reactivity in preclinical Alzheimer´s Disease (AD). However, most evidence to date comes from ultrasen...

Abstract Objective To investigate whether virtual unenhanced (VUE) images generated from spectral CT using the rapid kVp switching technique can serve as a substitute for true unenhanced (TUE) images in the assessment of...

Abstract Medical images are inherently high-resolution and contain locally varying structures that are crucial for diagnosis. Efficient compression of such data must therefore preserve diagnostic fidelity while minimizin...

Abstract Background Early detection of renal involvement in ANCA-associated vasculitis (AAV) is crucial, as functional changes often precede anatomical damage. Current diagnostic standards, such as the measurement of ser...

Abstract Background Acute myocardial infarction (AMI) is a critical and fatal cardiovascular condition. The role of cuproptosis as an emerging mechanism in the pathogenesis of AMI remains to be fully elucidated. Methods ...

Abstract Background Leishmaniasis is a vector-borne parasitic disease caused by Leishmania protozoa. The disease manifests in several clinical presentations including cutaneous, mucocutaneous, and visceral leishmaniasis....

Abstract Background Primary care is increasingly tasked with early detection, diagnosis, and management of dementia. Despite policy initiatives, education investments, and development of diagnostic and care pathways in A...

Abstract Neoadjuvant chemotherapy (NAC) induces critical morphological and vascular changes in breast cancer tumors, yet existing deep learning techniques in medical imaging tend to neglect these longitudinal changes thr...

Abstract Alzheimer’s disease (AD) is a prevalent and progressive neurodegenerative disease characterized by behavioral abnormalities, memory loss, and cognitive decline, presenting significant challenges for early diag...

Abstract Background Sarcopenia, altered bone and systemic metabolism, physical frailty and cognitive decline are age-dependent and interrelated phenomena. Sleep disorders which are erroneously considered as part of the a...