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Abstract Background The European Reference Network for rare Inherited and Congenital Anomalies (ERNICA) aims to improve care for patients with rare and complex digestive and gastrointestinal diseases across Europe throug...

Abstract Background Mesenchymal stem cells (MSCs) have become a promising treatment of liver fibrosis which is a key process in liver diseases. Recent studies have shown that transplanted MSCs undergo rapid apoptosis and...

Abstract Background Pancreatic portal hypertension (PPH) is a distinct form of sinistral (left-sided) portal hypertension, primarily resulting from pancreatic diseases such as acute or chronic pancreatitis and pancreatic...

Abstract Background I Kappa B Kinase Interacting Protein (IKBIP) has been reported to promote tumor progression in diverse cancers. however, the role of IKBIP in hepatocellular carcinoma (HCC) has remained unclear. Metho...

Abstract Objective This study aims to evaluate the clinical features, efficacy of endoscopic therapy, and long-term prognosis in patients with ectopic papilla of Vater (EPV) located in the duodenal bulb. Methods A retros...

Abstract Objectives Gastroesophageal reflux disease (GERD) is estimated to affect up to one-quarter of the Italian population, generating immense treatment costs. An emergent surgical treatment involving implantation of ...

Abstract Background Cryptosporidium spp. is an important intestinal protozoan parasite causing morbidity and mortality in immunocompromised patients, particularly those with HIV+/AIDS. A cross-sectional study was conduct...

Abstract Background Colorectal signet ring cell carcinoma (CSRCC) is a rare subtype of colorectal cancer characterized by an exceptionally poor prognosis. Currently, accurate survival prediction models for CSRCC are lack...

Abstract Objective Current diagnostic paradigms for Crohn’s disease (CD) activity assessment remain fragmented across imaging and laboratory modalities. This study seeks to investigate the diagnostic efficacy of intest...

Abstract Background Gastrointestinal dysfunction is a common and detrimental complication following stroke, closely linked to poor outcomes. Emerging evidence implicates gut microbiota dysbiosis and intestinal barrier di...

Abstract Objective To assess the level of fear of disease progression (FoP) in patients with acute pancreatitis (AP) during early hospitalization and identify its influencing factors. Methods This cross-sectional study w...

Abstract Background This study investigates the impact of chronic hepatitis B virus infection on triglyceride metabolism through alterations in the gut microbiome, using a faecal microbiota transplantation (FMT) mouse mo...

Abstract Objective This study aimed to systematically identify and validate KIF15 as a potential diagnostic and prognostic biomarker in colon cancer (CC) using integrated bioinformatics analyses. We further explored its ...

Abstract Background While diabetes mellitus (DM) has been reported as a risk factor for development and prognosis of pancreatic ductal adenocarcinoma (PDAC), the specific impact of glycemic control on clinical outcomes r...

Abstract Background Sorafenib has served as standard treatment for advanced hepatocellular carcinoma (HCC). Recently, several randomized controlled trials (RCTs) have explored the use of programmed cell death protein 1/p...

Abstract Background and aims Pancreatic duct leaks and fistulas are challenging complications of pancreatitis and pancreatic surgery. Although endoscopic retrograde pancreatic duct drainage (ERPD) is widely used, optimal...

Abstract Introduction Dyspepsia affects 6.9% of people globally and significantly impairs quality of life, yet it often remains undiagnosed. Undiagnosed dyspepsia (UD) affects up to one-third of patients and is prevalent...

Abstract Background Shigella species are a significant global public health threat with the highest burden of Shigella-associated diarrhoea in children under five years of age, particularly in low- and middle-income coun...

Abstract Background Sleep impairment is common in ulcerative colitis (UC) and may persist during clinical remission. This study evaluated the clinical, inflammatory, metabolic, and behavioral features to better character...

Abstract Background Postoperative biliary and vascular complications (including stenosis, thrombosis, and occlusion) after liver transplantation (LT) can impair graft function, increase reoperation needs, and elevate pat...

Abstract Background The recurrence of small intestinal hemorrhage (SIH) poses a significant clinical challenge owing to the absence of reliable and accessible predictive biomarkers. This study aimed to identify a crucial...

Abstract Objectives Gastrointestinal neuroendocrine neoplasms (GI-NENs) exhibit heterogeneity in biological behavior, making it difficult to predict prognosis. We established the P Grade based on 68Ga-DOTANOC and 18F-FDG...

Abstract Background The Achalasia Patient Reported Outcomes (APRO) questionnaire is developed to assess the frequency and severity of achalasia symptoms in adults with achalasia. The aim of this study was to translate th...