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Abstract Background Life expectancy increases, leading to growth in an older population where frailty and comorbidities are more prevalent. Subsequent increased intensive care unit (ICU) treatment results in prolonged re...

Abstract Objectives The relationship between metabolic dysregulation and frailty remains incompletely understood. This study examines the association between metabolic dysregulation and frailty in middle-aged and older a...

Abstract Background Frailty is a known predictor of adverse surgical outcomes, yet its influence on functional recovery trajectories in South Asian settings remains underexplored. This study evaluated the association bet...

Abstract Objective Given the increased risk of frailty among middle-aged and older adults with obesity, we aimed to develop and validate a predictive model for incident frailty among adults aged ≥ 45 years with obe...

Abstract Background Oral frailty is a key determinant of older adults’ health, functional independence, and quality of life. However, its core elements and interrelationships lack clear systematic conceptualization, an...

Abstract Background Oral frailty is a significant risk factor for systemic frailty and poor health outcomes in older adults. While oral health care interventions may mitigate this decline, the evidence remains fragmented...

Abstract Background Frailty is strongly associated with adverse outcomes including depression, cognitive decline, falls, and reduced quality of life. Frailty is an important indicator of older individuals’ health statu...

Abstract Objective This study aimed to explore self-perceptions and embodied experiences of different dimensions of frailty among older adults with hip fracture, to complement objective frailty assessment and inform the ...

Abstract Background Population ageing presents increasing challenges for health systems. Identifying complex needs and planning individualized care through Comprehensive Geriatric Assessment (CGA), promoting intergenerat...

Abstract Background Adverse events across the lifespan have been linked to poorer health outcomes, but the biological mechanisms remain unclear. The aim of this study was to quantify the independent and joint association...

Abstract Introduction The ageing of the population is expected to increase the costs and consumption of health care. Care should be patient-centred. Patient-centred care (PCC) has been shown to increase the quality of li...

Abstract Introduction As the population ages, non–ST-segment elevation myocardial infarction (NSTEMI) in the oldest-old poses unique management challenges, yet this group remains underrepresented in clinical trials. He...

Abstract Background Sarcopenia, the age-related loss of muscle mass and strength, is a leading cause of disability and frailty in older adults. Though primarily seen as a musculoskeletal condition, emerging evidence sugg...

Abstract Background Physical exercise has emerged as a promising non-pharmacological approach for improving cognitive and physical function in older adults with mild cognitive impairment (MCI). However, most existing int...

Abstract Introduction The geriatric population is the fastest-growing age group and accounts for one-third of surgical patients. A growing body of evidence reveals that postoperative cognitive dysfunction (POCD) is the m...

Abstract Background Diabetes is associated with a high incidence of diabetic foot and peripheral artery disease and with markedly increased lifetime amputation risk. Here we investigated predictors of reamputation risk a...

Abstract Background Sarcopenia, altered bone and systemic metabolism, physical frailty and cognitive decline are age-dependent and interrelated phenomena. Sleep disorders which are erroneously considered as part of the a...