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Abstract Background Carotid atherosclerosis is a kind of systemic atherosclerosis in the carotid arteries. It remains one of the leading causes of ischemic stroke. However, the efficiency of treatment is insufficient. Th...

Abstract Background Leishmaniasis is a vector-borne disease caused by a protozoan parasite of the genus Leishmania. The infection is transmitted by the bite of infected female sandflies of the genus Phlebotomus in the Ol...

Abstract Accurate assessment of Human Epidermal Growth Factor Receptor 2 (HER2) immunohistochemistry (IHC) expression, particularly the precise identification of “HER2 ultra-low” status, is critical for guiding antib...

Abstract Background Despite ongoing reports of malaria from health facilities in central Ethiopia, entomological evidence on local vectors remains scarce. This study investigated Anopheles species composition, host prefe...

Abstract Background Reliable identification of protein‑protein interactions (PPIs) is crucial for deciphering cellular functional networks. Current research models still face limitations in aligning heterogeneous featu...

Abstract Background Super-enhancers are critical cis-regulatory elements that play a central role in modulating gene expression and driving cellular identity. Their dysregulation is closely associated with the developmen...

Abstract Background Progressive retinal atrophy (PRA) was diagnosed in four related male English Cocker Spaniels (ECS) between the ages of 3 and 4 years. All affected dogs were born to clinically unaffected parents that ...

Abstract Background Tick-borne encephalitis virus (TBEV, Orthoflavivirus encephalitidis) is an arbovirus of the family Flaviviridae. It is the etiological agent of tick-borne encephalitis (TBE), a severe disease affectin...

Abstract Background To improve the visualisation of colorectal cancer (CRC) and its metastatic lymph nodes (LNs), we developed a second near-infrared window (NIR-II; 1000–1700 nm) fluorescent probe using a monoclonal ...

Abstract Background Nipple discharge is one of the most common breast complaints, reported by 80% of women outside the breastfeeding period. It may result from physiological or pathological causes, including intraductal ...

Abstract Background Staphylococcus aureus (S. aureus) is a versatile pathogen which colonizes food-producing animals and causes infections in humans. This study aims to determine the prevalence of 1. S. aureus in broiler...

Abstract Background Ticks are important ectoparasites for both humans and animals and can also transmit a wide range of different viral, bacterial, and parasitic pathogens, which are commonly known as “tick-borne patho...

Abstract Background Though being prevalent worldwide, Mansonella parasites are among the most neglected filarial nematodes. The true prevalence and genetic diversity of this genus have yet to be fully understood. Mansone...

Abstract Background Infections caused by members of the Mycobacterium fortuitum complex are generally mild and confined to skin and soft tissues, while severe disease in immunocompetent individuals is uncommon. Within th...

Abstract Cerebral cavernous malformations (CCMs) are vascular lesions associated with severe neurological complications. Increasing evidence suggests that cancer-like mechanisms, like an abnormal expansion of CCM3 knocko...