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Abstract Background Triggering receptor expressed on myeloid cell-2 (TREM2) signaling promotes disease-associated microglia (DAM) and phagocytosis in neurodegenerative diseases. Traditional anti-TREM2 agonist antibodies ...

Abstract Accumulation of amyloid beta 1–42 (Aβ42) peptide in the extracellular space in the brain is a major observation in Alzheimer’s Disease (AD)-related pathology. Astrocytes are known to play pivotal role in cl...

Abstract Mutations in the presenilin (PS/PSEN) genes cause early-onset familial Alzheimer’s disease (AD) by enhancing cerebral accumulation of amyloid-β (Aβ) peptides and microtubule-associated protein tau (MAPT). Ho...

Abstract Accurate assessment of Human Epidermal Growth Factor Receptor 2 (HER2) immunohistochemistry (IHC) expression, particularly the precise identification of “HER2 ultra-low” status, is critical for guiding antib...

Abstract The status of human epidermal growth factor receptor 2 (HER2) is a critical determinant of breast cancer progression and outcome, but the role of glycosylation in modulating HER2-related pathways remains poorly ...

Abstract Background Abdominal pregnancy refers to the implantation of a fertilized egg in the abdominal cavity outside of the uterus, fallopian tubes, and ovaries; splenic pregnancy is a rare type of abdominal pregnancy....

Abstract Background During infection, alterations of the endothelium’s barrier function are multifaceted and virus-specific. Rubella virus (RuV) infection during pregnancy damages the endothelium in the placental and f...

Abstract Background ADAM10 and ADAM17, members of the membrane-bound disintegrin metalloproteinase (ADAM) family, act as α-secretases in the non-amyloidogenic processing of the amyloid precursor protein. While alteratio...