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Abstract Background Critically ill patients in intensive care units (ICUs) are at risk for colonization and infection by carbapenem-resistant Acinetobacter baumannii (CRAB), a multidrug-resistant pathogen with high morta...

Abstract Background Metagenomic next-generation sequencing (mNGS) emerging as a standout in the clinical setting. In this study, we harnessed the power of mNGS to explore the pathogenic spectrum and temporal variations i...

Abstract Background The global rise of multidrug-resistant Enterobacterales, particularly extended-spectrum beta-lactamase (ESBL)- and carbapenemase-producing Escherichia coli and Klebsiella pneumoniae, poses a critical ...

Abstract Background Bacillus cereus is an emerging cause of fulminant nosocomial bacteremia in premature infants. Here we aimed to report the successful management of two successive waves of contamination, colonization a...

Abstract Background In intensive care units, critically ill patients often require life-sustaining interventions. When these no longer benefit the patient, care is often transferred to end-of-life care. Family members ma...

Abstract Background Mortality prediction in critically ill patients is commonly performed with scoring systems such as SOFA and APACHE II. The arterial-to-end-tidal carbon dioxide gradient [P(a–et)CO₂], which can be ...

Abstract Background Chikungunya virus (CHIKV) infection can progress to severe clinical forms requiring intensive care. This study aimed to characterize adult patients admitted to intensive care units (ICUs) with CHIKV d...

Abstract Background Life expectancy increases, leading to growth in an older population where frailty and comorbidities are more prevalent. Subsequent increased intensive care unit (ICU) treatment results in prolonged re...

Abstract Background Klebsiella pneumoniae complex (Kp) is a relevant neonatal pathogen colonizing preterm infants. While outbreak investigations often focus on multidrug-resistant strains, the epidemiology and genomic dy...

Abstract Background Current guidelines recommend baseline insulin as the standard treatment for most people hospitalised with type 2 diabetes (PWT2D). However, they generally discourage the use of sodium–glucose cotran...

Abstract Background Invasive candidiasis (IC) remains a major cause of morbidity and mortality worldwide, particularly among critically ill and immunocompromised patients. The emergence of antifungal resistance, especial...

Abstract Background Furosemide is commonly used off-label in the neonatal intensive care unit to promote diuresis and improve pulmonary mechanics in preterm infants, but prolonged exposure carries known renal and ototoxi...

Abstract Background Nurses frequently care for patients at the end of life, yet many lack adequate preparation to manage the associated emotional challenges. Attitudes toward death influence both the quality of end-of-li...

Abstract Purpose The aim of this study was to investigate the hypothesis that pregnant women diagnosed with bacterial vaginosis (BV) may encounter more adverse outcomes during induced labour. Methods The study population...

Abstract Background Prone positioning is recommended for patients with acute respiratory distress syndrome not only to improve oxygenation, but also to reduce lung stress, and lower mortality. The association between imp...