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Abstract Background Tuberculous pericardial effusion (TPE) presents significant diagnostic challenges due to its nonspecific clinical presentation and similarities with other types of pericardial effusion. The available ...

Abstract The Internet plays a pivotal role in tackling global climate challenges, particularly in facilitating a transition toward low-carbon behavior. However, the mechanisms by which the Internet shapes low-carbon beha...

Abstract Backgrounds Neoadjuvant chemoradiation (nCRT) is a standard treatment for rectal carcinoma that reduces tumor size and local recurrence while improving the rate of sphincter preservation. However, many patients ...

Abstract Purpose This study aimed to identify the effectiveness of free water MRI (FW-MRI) features for predicting amyloid-beta (Aβ) statuses in Alzheimer’s disease (AD) by constructing diagnostic models using machine...

Abstract Background Carotid atherosclerosis is a kind of systemic atherosclerosis in the carotid arteries. It remains one of the leading causes of ischemic stroke. However, the efficiency of treatment is insufficient. Th...

Abstract Background Interstitial lung disease (ILD) is characterized by marked heterogeneity and an overall poor prognosis, with many patients experiencing rapid progression and high short-term mortality. Accurate early ...

Abstract Background Accurate prediction of response to neoadjuvant chemoradiotherapy (nCRT) in patients with locally advanced rectal cancer (LARC) is essential for optimizing treatment decisions. This study aimed to deve...

Abstract Background Chronic conditions cause millions of deaths annually worldwide. Remote patient monitoring using wearable devices and sensors, combined with machine learning (ML), offers promising strategies for disea...

Abstract Background Understanding how the respiratory microbiota matures with age is key to improving poultry health and pathogen surveillance, yet the ecological processes shaping this transition remain elusive. We aime...

Abstract Background The prognosis and progression mechanisms of bladder cancer (BLCA) are highly heterogeneous, driven by complex genetic and epigenetic alterations. This study aimed to construct a robust prognostic sign...

Abstract Background Postoperative complications of mediastinal tumors significantly impact patients’ quality of life and long-term outcomes; however, a notable gap in the development of predictive tools for their occur...

Abstract Background Optimization of biotechnological processes is traditionally limited by time-consuming trial-and-error approaches and the complexity of simultaneously optimizing multiple, often conflicting objectives....

Abstract Background Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder that is linked to cardiovascular, metabolic, and neurocognitive complications. However, its diagnosis relies on polysomnograp...

Abstract Background Lung adenocarcinoma (LUAD) is a predominant contributor to cancer‑related mortality globally. Lung‑associated fibroblasts (LAFs) are intricately linked to tumorigenesis and the tumor microenvironm...

Abstract Background Small cell lung cancer (SCLC) is an aggressive neuroendocrine malignancy characterized by rapid progression and poor prognosis. This study integrates bioinformatics with experimental validation to cha...

Abstract Background Pediatric sepsis remains a leading cause of global mortality, necessitating early and accurate risk stratification. Traditional scoring systems often fail to capture the rapid, non-linear progression ...