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13 resultados encontrados.

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Dysfunctional astrocytes regulate excitatory neurons via cell adhesion and vascular lesions in patients with Alzheimer’s disease
Artículo
Acceso abierto Artículo DOAJ
Dysfunctional astrocytes regulate excitatory neurons via cell adhesion and vascular lesions in patients with Alzheimer’s disease
Yuan-Yuan Zhang et al · BMC · 2026 · ISSN 1479-5876
Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. Its complex pathogenesis remains unclear, and no specific drugs are available for treatment. Current treatments focus mainly on ...
LCC LCC:MedicineIdioma eng
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Targeting p75NTR activity alleviates the neurotoxic effect of high glucose on iPSC-derived dopaminergic neurons
Artículo
Material complementario disponible Artículo DOAJ
Targeting p75NTR activity alleviates the neurotoxic effect of high glucose on iPSC-derived dopaminergic neurons
Konstantina Chanoumidou et al · BMC · 2026 · ISSN 1757-6512
Abstract Background Hyperglycemia, a hallmark of diabetes mellitus, is a metabolic condition that highly affects the nervous system. While evidence from epidemiological and animal studies links diabetes to dopaminergic d...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~; TENDOkJpb2NoZW1pc3RyeQ~~Idioma eng
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A new dawn for Parkinson’s disease: commentary on the emergence of stem cell-based therapies
Artículo
Acceso abierto Artículo DOAJ
A new dawn for Parkinson’s disease: commentary on the emergence of stem cell-based therapies
Rosalie Elvira et al · BMC · 2026 · ISSN 2047-9158
Abstract The field of regenerative medicine for Parkinson’s disease (PD) has reached a pivotal moment. After decades of preclinical research, recent first-in-human clinical trials demonstrated that cell replacement the...
LCC LCC:Neurology. Diseases of the nervous systemIdioma eng
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A brainstem–thalamocortical circuit mediates postoperative pain duration induced by sleep deprivation
Artículo
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A brainstem–thalamocortical circuit mediates postoperative pain duration induced by sleep deprivation
Lei Li et al · BMC · 2026 · ISSN 1744-9081
Abstract Background Postoperative sleep disturbances are common and have been shown to exacerbate incisional pain by enhancing the central nervous system’s excitability. However, the specific neural circuit mechanisms ...
LCC LCC:Neurology. Diseases of the nervous systemIdioma eng
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Ciliary p75 neurotrophin receptor (p75NTR) facilitates the enrichment of exogenous amyloid beta (Aβ 1–42) peptide and promotes oxidative stress in human hippocampal astrocytes
Artículo
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Ciliary p75 neurotrophin receptor (p75NTR) facilitates the enrichment of exogenous amyloid beta (Aβ 1–42) peptide and promotes oxidative stress in human hippocampal astrocytes
Ankan Gupta et al · BMC · 2026 · ISSN 2661-8850
Abstract Accumulation of amyloid beta 1–42 (Aβ42) peptide in the extracellular space in the brain is a major observation in Alzheimer’s Disease (AD)-related pathology. Astrocytes are known to play pivotal role in cl...
LCC LCC:CytologyIdioma eng
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Detection of collagen band–associated regions in H&E-stained colonic biopsies of collagenous colitis patients using superpixel-based feature extraction and neural network classification
Artículo
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Detection of collagen band–associated regions in H&E-stained colonic biopsies of collagenous colitis patients using superpixel-based feature extraction and neural network classification
Vytautas Kiudelis et al · BMC · 2026 · ISSN 1746-1596
Abstract Background Collagenous colitis (CC) is diagnosed histologically and is characterised by a thickened subepithelial collagen band together with inflammatory and epithelial changes. Although routine haematoxylin an...
LCC TENDOlBhdGhvbG9neQ~~Idioma eng
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Features of the land use and COVID-19 cases and deaths in urban and land counties in Poland throughout the pandemic: a machine learning approach
Artículo
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Features of the land use and COVID-19 cases and deaths in urban and land counties in Poland throughout the pandemic: a machine learning approach
Roman Suligowski et al · BMC · 2026 · ISSN 1471-2458
Abstract Background The research shows the impact of land use forms and population density on the spatial variation of COVID-19 cases and deaths. Selected elements of land use that influence the number of COVID-19 cases ...
LCC LCC:Public aspects of medicineIdioma eng
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Glutamatergic pathway from deep layers of the insular cortex to the rostral central medial thalamic nucleus participates in neuropathic pain and anxiety-like behaviors in mice
Artículo
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Glutamatergic pathway from deep layers of the insular cortex to the rostral central medial thalamic nucleus participates in neuropathic pain and anxiety-like behaviors in mice
Xiao Ren et al · BMC · 2026 · ISSN 1129-2377
Abstract Background The insular cortex (IC), a pivotal hub for pain signal integration, projects extensively to the thalamus. However, the functional role of its specific projection to the central medial thalamic nucleus...
LCC LCC:MedicineIdioma eng
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N-terminally acetylated Met11-Tau: a new pathological truncated Tau species with functional relevance in Alzheimer's disease
Artículo
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N-terminally acetylated Met11-Tau: a new pathological truncated Tau species with functional relevance in Alzheimer's disease
Sarah Guedjdal et al · BMC · 2026 · ISSN 2047-9158
Abstract Background Tauopathies are a group of neurodegenerative diseases, including Alzheimer’s disease (AD), characterized by progressive accumulation of pathological Tau proteins. Among the diverse Tau species, trun...
LCC LCC:Neurology. Diseases of the nervous systemIdioma eng
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Phosphatidylinositol transfer protein-1 integrates insulin/IGF-1 and TOR signaling to negatively regulate lifespan and healthspan in Caenorhabditis elegans
Artículo
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Phosphatidylinositol transfer protein-1 integrates insulin/IGF-1 and TOR signaling to negatively regulate lifespan and healthspan in Caenorhabditis elegans
Yen-Hung Lin et al · BMC · 2026 · ISSN 1423-0127
Abstract Background Phosphatidylinositol transfer protein-1 (pitp-1) is involved in the phosphoinositide (PIP) cycle. The role of pitp-1 in promoting healthy longevity remains unknown. Our previous work showed that the P...
LCC LCC:MedicineIdioma eng
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Presenilin-dependent regulation of neuronal tau pathology via the autophagy and proteasome pathways
Artículo
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Presenilin-dependent regulation of neuronal tau pathology via the autophagy and proteasome pathways
Anna del Ser-Badia et al · BMC · 2026 · ISSN 2051-5960
Abstract Mutations in the presenilin (PS/PSEN) genes cause early-onset familial Alzheimer’s disease (AD) by enhancing cerebral accumulation of amyloid-β (Aβ) peptides and microtubule-associated protein tau (MAPT). Ho...
LCC LCC:Neurology. Diseases of the nervous systemIdioma eng
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Selective reduction of ADAM10 in brain and cerebrospinal fluid of Alzheimer’s disease patients
Artículo
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Selective reduction of ADAM10 in brain and cerebrospinal fluid of Alzheimer’s disease patients
Adriana Gea-González et al · BMC · 2026 · ISSN 1758-9193
Abstract Background ADAM10 and ADAM17, members of the membrane-bound disintegrin metalloproteinase (ADAM) family, act as α-secretases in the non-amyloidogenic processing of the amyloid precursor protein. While alteratio...
LCC LCC:Neurosciences. Biological psychiatry. Neuropsychiatry; LCC:Neurology. Diseases of the nervous systemIdioma eng
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The medial orbitofrontal cortex mediates neuropathic pain and anxiodepressive-like behaviors via two distinct pathways
Artículo
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The medial orbitofrontal cortex mediates neuropathic pain and anxiodepressive-like behaviors via two distinct pathways
Zhixiao Li et al · BMC · 2026 · ISSN 1129-2377
Abstract Background Chronic neuropathic pain is frequently accompanied by anxiety and depression, yet the cortical circuit mechanisms underlying this comorbidity remain unclear. The medial orbitofrontal cortex (mOFC) is ...
LCC LCC:MedicineIdioma eng
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