NODOVOX | Discovery

Dysfunctional astrocytes regulate excitatory neurons via cell adhesion and vascular lesions in patients with Alzheimer’s disease

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Acceso abierto Artículo DOAJ

Dysfunctional astrocytes regulate excitatory neurons via cell adhesion and vascular lesions in patients with Alzheimer’s disease

Yuan-Yuan Zhang et al · BMC · 2026 · ISSN 1479-5876

Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. Its complex pathogenesis remains unclear, and no specific drugs are available for treatment. Current treatments focus mainly on ...

LCC LCC:MedicineIdioma eng

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Dysregulated m6A RNA methylation in tuberculosis: association with altered methyltransferase expression and immune responses

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Dysregulated m6A RNA methylation in tuberculosis: association with altered methyltransferase expression and immune responses

Yunyi Xu et al · BMC · 2026 · ISSN 1471-2334

Abstract Objective Tuberculosis (TB) remains a global health threat with an incompletely understood pathogenesis. The RNA epigenetic modification N6-methyladenosine (m6A) is a key regulator of immune responses in various...

LCC TENDOkluZmVjdGlvdXMgYW5kIHBhcmFzaXRpYyBkaXNlYXNlcw~~Idioma eng

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Multi-omics analysis reveals the critical role of gut microbiota related tryptophan and glutathione metabolism in sepsis-associated encephalopathy

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Multi-omics analysis reveals the critical role of gut microbiota related tryptophan and glutathione metabolism in sepsis-associated encephalopathy

Xiaomin Hu et al · BMC · 2026 · ISSN 1471-2180

Abstract Background Recent studies highlight the critical role of gut microbiota in sepsis pathogenesis and its potential link to neurological disorders, particularly sepsis-associated encephalopathy (SAE). However, the ...

LCC TENDOk1pY3JvYmlvbG9neQ~~Idioma eng

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Selective reduction of ADAM10 in brain and cerebrospinal fluid of Alzheimer’s disease patients

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Selective reduction of ADAM10 in brain and cerebrospinal fluid of Alzheimer’s disease patients

Adriana Gea-González et al · BMC · 2026 · ISSN 1758-9193

Abstract Background ADAM10 and ADAM17, members of the membrane-bound disintegrin metalloproteinase (ADAM) family, act as α-secretases in the non-amyloidogenic processing of the amyloid precursor protein. While alteratio...

LCC LCC:Neurosciences. Biological psychiatry. Neuropsychiatry; LCC:Neurology. Diseases of the nervous systemIdioma eng

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miR-326 promotes osteogenic differentiation of bone marrow mesenchymal stem cells by targeting NAT10

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miR-326 promotes osteogenic differentiation of bone marrow mesenchymal stem cells by targeting NAT10

Yuanbin Zhang et al · BMC · 2026 · ISSN 1749-799X

Abstract Objectives Abnormal osteogenic differentiation of BMSCs is a core factor in osteoporosis (OP). This study investigates how miR-326 regulates osteogenic differentiation of hBMSCs by targeting NAT10, thereby influ...

LCC TENDOk9ydGhvcGVkaWMgc3VyZ2VyeQ~~; LCC:Diseases of the musculoskeletal systemIdioma eng

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