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Abstract Background and aims Vascular Ehlers-Danlos syndrome (vEDS) is a rare genetic disorder characterized by connective tissue fragility; however, respiratory manifestations such as pulmonary hemorrhage and spontaneou...

Abstract Background Studies have shown that autophagy was closely involved in host defense against mycobacteria, and genetic variations in autophagy genes were related to susceptibility to multiple diseases. We conducted...

Abstract Tuberculosis (TB) has high morbidity and mortality rates, and drug-resistant strains pose an increasing challenge. Traditional methods for detecting the Mycobacterium tuberculosis complex (MTBC) are insufficient...

Abstract Background Patients with AIDS Suffering from sepsis secondary to pulmonary infections admitted to intensive care units (ICUs) carry a high burden of morbidity and mortality. Therefore, rapid identification and t...

Abstract Background Pulmonary cryptococcosis (PC) is increasingly diagnosed in human immunodeficiency virus (HIV)-negative and apparently immunocompetent individuals. A critical complication of PC is dissemination to the...

Abstract Background Blood eosinophil count is an accepted biomarker for type 2 inflammation in COPD. However, the majority of COPD patients are characterized by non-type 2 inflammation. We aimed to test readily obtainabl...

Abstract Background Fat embolism syndrome (FES) is commonly associated with orthopedic trauma, but the diagnosis is challenging with an uncommon nontraumatic cause. It is difficult to discriminate from thrombo-embolism i...

Abstract Objective Tuberculosis (TB) remains a global health threat with an incompletely understood pathogenesis. The RNA epigenetic modification N6-methyladenosine (m6A) is a key regulator of immune responses in various...

Abstract Background Chronic conditions cause millions of deaths annually worldwide. Remote patient monitoring using wearable devices and sensors, combined with machine learning (ML), offers promising strategies for disea...

Abstract Background Pediatric connective tissue disease-associated interstitial lung disease (CTD-ILD) is a rare but serious condition with limited clinical data; this study aimed to evaluate its clinical features, treat...

Abstract Background Bordetella pertussis (BP) infection has risen rapidly in pediatrics recently, and next-generation sequencing has significantly improved pertussis’ early diagnosis. High detection rates raise the con...

Abstract Objective Voriconazole is a commonly used antifungal medication, particularly for treating invasive pulmonary aspergillosis and as prophylaxis in hematologic malignancies. However, it can cause adverse effects, ...