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Abstract Purpose This study aims to investigate the mechanisms underlying ANXA1 and HMGB1-regulated autophagy in relation to growth and radioresistance in thyroid cancer cells. This exploration seeks to provide new theor...

Abstract Objective To investigate whether serum lysyl oxidase-like 2 (LOXL2) and chitinase-3-like protein 1 (YKL-40) levels are associated with drug-resistant Mycobacterium tuberculosis in children with pulmonary tubercu...

Abstract Background Cold water immersion (CWI) is a common method of post-exercise recovery, but the optimal protocols are not well understood. The lack of exercise-specific guidelines has caused confusion on how CWI sho...

Abstract Background High-throughput sequencing (HTS) enables the detection of low-frequency HIV-1 drug resistance mutations (DRMs) that are often missed by conventional Sanger sequencing. However, the clinical implementa...

Abstract Background Estrogen receptor alpha (ERα)-positive luminal breast cancer is commonly treated with aromatase inhibitors (AI) to block estrogen signaling; however, resistance frequently develops, limiting therapy ...

Abstract Objective By using molecular network technology to analyze the transmission characteristics of the CRF55_01B strain in Yunnan Province, we aimed to identify high-risk transmitters, trace the origin time, locatio...

Abstract Radiotherapy resistance (RT resistance) remains a major obstacle in lung adenocarcinoma (LUAD) treatment, with dysregulated apoptosis being a key contributor. This study aim to investigate the role of PDPK1 in R...

Abstract Human Immunodeficiency Virus / Acquired Immunodeficiency Syndrome (HIV/AIDS) is a major public health problem affecting an estimated 38.4 million people globally, with 54% of them being from the Eastern and Sou...

Abstract In response to the emerging threat of insecticide resistance in malaria vectors, insecticides are being repurposed for vector control or developed de novo. The longevity of disease control programs will require ...

Abstract Background Late blight, caused by Phytophthora infestans, is one of the most destructive diseases threatening global potato production. Methods To investigate the molecular basis of resistance, we conducted inte...

Abstract Background Pyrethroid resistance continues to undermine malaria vector control across Africa, particularly in agricultural hotspots where insecticide pressure is high. However, the molecular mechanisms enabling ...

Abstract Background Antimicrobial resistance (AMR) represents a major global One Health challenge, with increasing recognition of the role of wildlife in the environmental circulation of resistant bacteria. Wild birds, p...

Abstract Background Direct contact with their offspring during the first few weeks makes sows a potential source of resistant bacteria for fattening pigs and food products derived from pigs. Moreover, staff working with ...

Abstract Background Fusarium crown rot (FCR) caused by species of Fusarium fungus is a global soil-borne disease of wheat. Increasing results indicate frequent controversy between seedling and adult plant resistance to F...

Abstract Aim (Background) The purpose of the current in vitro study was to evaluate and compare the marginal adaptation and fracture resistance of CAD/CAM VITA ENAMIC hybrid ceramic and, 3D printed Nanoksa G-PLUS high-pe...

Abstract Background The emergence of tmexCD-toprJ, a plasmid-mediated resistance-nodulation-division efflux pump gene cluster conferring resistance to tigecycline, poses a critical public health threat. While its prevale...

Abstract Background Antimicrobial resistance (AMR) is a growing threat to public health, especially in low- and middle-income countries. This study aimed to identify multidrug-resistant (MDR) pathogens in clinical sample...

Abstract Background The global rise of multidrug-resistant Enterobacterales, particularly extended-spectrum beta-lactamase (ESBL)- and carbapenemase-producing Escherichia coli and Klebsiella pneumoniae, poses a critical ...

Abstract Background Invasive candidiasis (IC) remains a major cause of morbidity and mortality worldwide, particularly among critically ill and immunocompromised patients. The emergence of antifungal resistance, especial...