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Abstract Objective Tuberculosis (TB) remains a global health threat with an incompletely understood pathogenesis. The RNA epigenetic modification N6-methyladenosine (m6A) is a key regulator of immune responses in various...

Abstract Background Preeclampsia (PE), a life-threatening hypertensive disorder of pregnancy, remains poorly characterized at the post-transcriptional regulation level. While alternative splicing (AS) perturbations drive...

Abstract Long-read transcriptome sequencing (long-RNA-seq) revolutionizes transcriptome research by enabling full-length transcript analysis for comprehensive exploration of isoform diversity. We developed IFDlong, a pro...

Abstract Background The dysfunction of osteoblasts has been identified as a pivotal contributor to bone erosion in rheumatoid arthritis (RA). Emerging evidence shows long non-coding RNAs (lncRNAs) as important regulators...

Abstract Dysregulated expression of tumor suppressor genes can impair their functions, even promoting oncogenesis. Expression of p53β mRNA can be regulated by alternative splicing and RNA surveillance, otherwise transla...

Abstract Background In photosynthetic eukaryotes of the green lineage, the expression of the chloroplast genome is mainly regulated post-transcriptionally, by RNA-binding proteins encoded in the nuclear genome termed org...

Abstract Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS) characterized by multifocal inflammation and axonal degeneration, driven by innate and adaptive immune cells. Th...

Abstract Vertebrate chemoreceptor genes play a central role in detecting environmental chemical compounds through the olfactory organs and taste buds, enabling the perception of odors and tastants that are critical for s...

Abstract Background Single-cell RNA sequencing (scRNA-seq) is considered a revolution in gene expression studies and offers significant benefits across various fields of biomedical or clinical applications. However, a hi...

Abstract Background and purpose Claudin-5 plays a crucial role in maintaining blood-brain barrier (BBB) integrity through endothelial tight junction formation. Alternative splicing of claudin-5 within the microvascular e...

Abstract The genomic locus that encodes the Leucine-rich repeat kinase 2 (LRRK2) gene is highly pleiotropic and associated with Parkinson’s disease (PD). Coding variants associated with risk of PD act as gain of functi...

Abstract Background Congenital anomalies of the kidney and urinary tract (CAKUT) comprise a heterogeneous group of developmental disorders with diverse genetic etiologies. However, it remains unclear whether these geneti...

Abstract Background Spaceflight introduces unique environmental stresses that challenge plant growth and development, necessitating an understanding of molecular responses to enable sustainable agriculture for long-durat...

Abstract Background Uveal melanoma (UM) is a rare disease, but the most common intraocular malignancy in adults, with incidence rates in Europe ranging from 1.3 to 8.6 cases per million annually. Although local tumor con...

Abstract Background The floral transition in maize represents a pivotal developmental switch that determines flowering time, environmental adaptation, and yield-related traits. However, the molecular mechanisms governing...

Abstract Influenza A virus (IAV) infections play a substantial role in human disease, hospitalization, and economic loss. In an effort to better understand the intracellular effects that IAV replication has on individual...

Abstract Background Epigenetic mechanisms including DNA methylation are assumed to play crucial roles in the maintenance of genome integrity, regulation of gene expression and development, and their increasing exploitati...

Abstract Background Immunological non-responders (INR), distinguished by profound immune dysfunction, fail to achieve immune reconstitution despite receiving antiretroviral therapy (ART). INR experience lower life expect...

Abstract Background Aging alters the systemic steroid environment, including reductions in circulating androgens. In peripheral tissues, androgen exposure is regulated mainly by local steroid metabolism, which can activa...

Abstract Background Triple-negative breast cancer (TNBC) is a subtype of breast cancer which has the poorest prognosis, with high recurrence and metastasis rates. ZNF503 (Zinc finger elbow-related proline domain protein ...

Abstract Brain pericytes are mediators of neuroinflammation, as evidenced in vitro, in animal models and humans. We and others have identified the platelet-derived growth factor (PDGF)-BB -PDGF receptor beta (PDGFRB) pat...

Abstract Non-small cell lung cancer (NSCLC) is a major cause of cancer-related mortality globally, linked to an immunosuppressive microenvironment. Circular RNA circSPARC is crucial in cancer, but its function in NSCLC r...

Abstract Background Primary pulmonary lymphoepithelial carcinoma (PPLEC) is an extremely rare subtype of lung squamous cell carcinoma (LUSC). This study aims to comprehensively characterize clinicopathological and molecu...

Abstract Aim Periodontitis can impair the osteogenic function of periodontal ligament stem cells (PDLSCs), thereby compromising their capacity for periodontal tissue regeneration. In this study, we explored the impact of...