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Abstract Background Optimization of biotechnological processes is traditionally limited by time-consuming trial-and-error approaches and the complexity of simultaneously optimizing multiple, often conflicting objectives....

Abstract Background This systematic review and meta-analysis evaluates the safety and efficacy of emerging prostate-specific membrane antigen (PSMA) radioligand therapy (RLT) agents used beyond [¹⁷⁷Lu]Lu-PSMA in met...

Abstract Purpose The past two decades witnessed increased use of risk-adjusted standardized measures such as standardized mortality ratios (SMRs) and standardized incidence ratios (SIRs) in institutional comparisons betw...

Abstract Objective This study aims to systematically review the impact of total screen time on university students' health outcomes and academic performance, and to explore its dose–response relationship. Methods The P...

Abstract Objective To systematically evaluate the efficacy differences between stereotactic radiosurgery (SRS) and whole-brain radiotherapy (WBRT) in treating brain metastases from small cell lung cancer (SCLC), and to a...

Abstract Background Diabetic Foot Ulcers (DFUs) represent a global healthcare challenge, imposing substantial socioeconomic burdens due to their increasing incidence and associated mortality. This study evaluates the eff...

Abstract Objective To accurately predict neurological outcomes among survivors after cardiac arrest (CA), we aim to analyze the experimental data of epileptiform electroencephalography (EEG) in CA survivors to explore th...

Abstract Background The clinical success of maxillary expansion depends largely on the degree of maturation of the midpalatal suture (MPS). Although cone-beam computed tomography (CBCT) allows direct visualisation of the...

Abstract Background As of 2025, cardiovascular disease (CVD) still remains a major threat to human life. Acute coronary syndrome (ACS) is still considered life-threatening and therefore prompt diagnosis and immediate int...

Abstract Background Oral frailty is a significant risk factor for systemic frailty and poor health outcomes in older adults. While oral health care interventions may mitigate this decline, the evidence remains fragmented...

Abstract Purpose Differential diagnoses of primary pancreatic lesions include pancreatic ductal adenocarcinomas (PDAC) and inflammatory lesions of the pancreas (ILP). Post-pancreatic surgery, differentiation of postopera...

Abstract Background Lupus retinopathy (LR) is a sight-threatening complication of systemic lupus erythematosus (SLE), yet disease-specific serologic biomarkers are lacking. Previous studies have shown that anti-recoverin...

Abstract The use of animal-borne devices to measure acceleration has yielded insights into animal locomotion, behaviour and energy expenditure. We present the first systematic review of accelerometry on animals, spanning...

Abstract Purpose Structured reporting (SR) offers standardized radiological documentation, enhancing clarity and reproducibility. However, its role in contrast-enhanced ultrasound (CEUS) for testicular tumors remains und...

Abstract This meta-analysis reveals a significant association between Body Mass Index (BMI) and the risk of osteoporosis. Being underweight may increase the risk of osteoporosis, while being overweight or obese may reduc...

Abstract Introduction Different pre-pregnancy body mass index (BMI) may lead to adverse pregnancy complications and unfavorable outcomes, but few studies focus on preterm infants under 32 gestational weeks. The associate...