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Abstract Background Patients with relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL) who failed bispecific antibody (BsAb) therapy face an extremely poor prognosis, necessitating exploration of effective salva...

Abstract Background Modern medical education is transforming from a biomedical focus toward a holistic, patient-centered paradigm that values medical humanistic qualities, such as empathy, communication skills and reflec...

Abstract Tuberculosis (TB) remains a major global public health challenge, with drug-resistant tuberculosis (DR-TB) presenting a serious threat to TB management. Conventional treatment faces challenges such as significan...

Abstract Background Chronic Insomnia Disorder (CID) is a prevalent condition. This study examines microbaric oxygen therapy (MOT) as a non-pharmacological intervention for CID patients, utilizing EEG to investigate its e...

Abstract Background Platinum-based chemoimmunotherapy is used as a first-line treatment for advanced gastric or gastroesophageal junction (G/GEJ) adenocarcinoma under specific regulatory circumstances, but effectiveness ...

Abstract Background Irritable bowel syndrome (IBS) is a prevalent disorder of gut-brain interaction in which psychosocial factors can exacerbate symptoms. Although cognitive behavioral therapy (CBT) has proven effective ...

Abstract PBRM1-mutant ccRCC is a subtype of ccRCC with limited treatment options. Currently, there were no effective drugs specifically targeting this mutation. Here, we discovered that PBRM1-mutant ccRCC patients with c...

Abstract Background The inability of antiretroviral medications to inhibit HIV is known as antiretroviral treatment failure. One of the greatest problems facing HIV patients receiving antiretroviral therapy is treatment ...

Abstract Background Limited evidence exists on the prescription patterns of combination antiretroviral therapy (cART) and their effectiveness in achieving HIV-1 viral suppression. This study evaluated pre-conflict prescr...

Abstract Background Adoptive cell therapy with tumour-infiltrating lymphocytes has been recognised as a safe and effective treatment for patients with advanced melanoma. Whether such a novel intervention is cost-effectiv...

Abstract Background Clinical responses to mesenchymal stromal cell (MSC) therapies remain variable because MSCs are often treated as uniform biologics despite donor-programmed differences. Evidence indicates that develop...

Abstract Background Malnutrition among hospitalized older adults in the United States is a growing public health concern associated with poor quality of life, increased mortality, higher readmission rates, and loss of in...

Abstract Background Stage III non-small cell lung cancer (NSCLC) is heterogeneous and poses significant treatment challenges. In recent years, neoadjuvant therapy has emerged as a promising treatment strategy for patient...

Abstract Background Occupational therapy practices are expanding in Turkey; however, pediatric professionals lack validated, client-centered assessment instruments for children with attention-deficit/hyperactivity disord...

Abstract Background Dolutegravir (DTG) is endorsed as a preferred option for both first- and second-line antiretroviral therapy (ART); however, comprehensive high-quality evidence regarding its virological effectiveness ...

Abstract Background Acute liver failure (ALF) is a life-threatening syndrome characterized by rapid deterioration of liver function, resulting in high mortality and posing a substantial global health burden. Human embryo...

Abstract Background The coexistence of renal artery stenosis (RAS) and acute tubulointerstitial nephritis (ATIN) is exceptionally rare. While imaging studies are essential for diagnosing RAS, noninvasive tests such as re...

Abstract Purpose To critically evaluate evidence supporting the angiogenesis-inflammation hypothesis in diabetic retinopathy (DR); to examine the roles of angiogenic growth factors and inflammatory cytokines in the bipha...

Abstract Background Alzheimer’s disease (AD) is a growing global health concern, and emerging evidence suggests that oral health—particularly tooth loss—may be linked to cognitive decline. While implant therapy eff...

Abstract Background Heart failure with preserved ejection fraction (HFpEF) disproportionately affects elderly women and is closely associated with central obesity and metabolic dysfunction. Although sodium-glucose co-tra...

Abstract Background Chikungunya virus (CHIKV) infection can progress to severe clinical forms requiring intensive care. This study aimed to characterize adult patients admitted to intensive care units (ICUs) with CHIKV d...

Abstract Background Prophylactic medications are commonly used to prevent tuberculosis and opportunistic infections in people living with HIV (PLWH) who are on first-line antiretroviral therapy (ART). However, their cumu...

Abstract Background Oxygen therapy is often lifesaving for critically ill patients with acute respiratory distress syndrome (ARDS). However, high oxygen doses may cause hyperoxic acute lung injury (HALI). In line with th...

Abstract Background Bone marrow-derived cell (BMDC) transplantation is increasingly recognized as a valuable strategy in regenerative therapies. However, the data regarding the impact of BMDC transplantation on the sever...