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Abstract Objective Intestinal organoids serve as important tools for drug screening, but the extent to which they recapitulate in vivo tissue microenvironments and drug responses remains inadequately evaluated. This s...

Abstract Objective The escalating threat of antimicrobial resistance poses significant clinical challenges, particularly in cases of co-infections involving Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA), ...

Abstract Objective To compare the differential activation characteristics of Toll-like receptor 5 (TLR5) agonist KFD and Toll-like receptor 7 (TLR7) agonist R837 on nasal epithelial cells (NECs) and bone marrow-derive...

Abstract Objective High-altitude chronic hypoxia can alter the immune status, yet the immune regulatory characteristics of various vaccine adjuvants in this environment remain to be fully elucidated. Accordingly, emph...

Abstract Objective China has achieved remarkable progress in tuberculosis (TB) control, with the incidence rates declining continuously; however, the disease burden among females remained substantial with pronounced r...

Abstract Vaccines represent the most cost-effective and efficacious approach for preventing gastrointestinal infections, and adjuvants play a pivotal role in enhancing and modulating immune responses. In this article, ...

Abstract Objective Posterior communicating artery aneurysm(PCoAA) exhibit complex anatomical relationships, and microsurgical clipping of large or posteromedially projecting aneurysms remains technically challenging w...

Abstract Objective Klebsiella pneumoniae (Kp) is a clinically prevalent opportunistic pathogen, with escalating antimicrobial resistance posing substantial challenges. Current vaccine strategies are constrained by the...

Abstract Objective Helicobacter pylori (Hp) infection is prevalent worldwide and represents a risk factor for various chronic inflammatory and neoplastic gastric diseases. In recent years, lipid nanoparticles (LNPs) h...

Abstract Objective Myelodysplastic syndromes (MDS) are associated with a high risk of progression to leukemia, highlighting the critical need to explore novel therapeutic agents. Based on network pharmacology predicti...

Abstract Objective Tissue-resident memory T (TRM) cells play a key role as “immune sentinels” in mucosal immune protection. However, the molecular regulatory mechanisms underlying the formation and long-term resid...

Abstract Objective Infertility represents a major global reproductive health challenge. Metabolite levels in both partners are highly correlated and may serve as potential confounders for each other. However, how the ...

Abstract Objective “One-stop” interventional therapy for non-valvular atrial fibrillation (NVAF) traditionally relies on transesophageal echocardiography (TEE) guidance, which carries limitations including anesthe...

Abstract Objective The pattern of socioeconomic status (SES) inequality across the natural history continuum of cervical cancer (from precancerous lesions to invasive cancer) remains unclear. This study aims to system...