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Objectives: By establishing a rat model of periapical infection, this study compared the anti‑inflammatory effects of caerin 1.1/1.9 hydrogel and calcium hydroxide paste, aiming to provide a novel therapeutic strategy ...

Introduction and aims: Submucous cleft palate (SMCP) is a congenital craniofacial malformation. While TBX22 is a known pathogenic gene, the potential role of TBX15 in SMCP remains unclear. This study aimed to investigate...

Background: Oral squamous cell carcinoma (OSCC) is a common oral cavity malignancy with a poor prognosis. Although chemokine-like receptor 1 (CMKLR1) has been implicated in tumor progression in several types of cancer, i...

Objective: The objective of this study was to synthesise a novel silver nanocomposite incorporating quorum-quenching enzyme N-acyl-homoserine lactone-lactonase Est816 (Ag-Est816) to inhibit periodontal biofilm formation....

In the search for new compounds for the treatment of Chagas disease, the cysteine protease cruzipain remains as one of the most attractive biomolecular targets for drug development. Thiosemicarbazones (TSCs) have been id...

Objectives: To comprehensively analyse the burden of five oral diseases in China, including caries of deciduous teeth, caries of permanent teeth, periodontal diseases, edentulism, and other oral disorders; compare their ...

Objective: Periodontitis is a chronic inflammatory disease that severely affects oral and general health. N7-methylguanosine (m7G) methylation plays critical roles in regulating gene expression and cellular functions. Me...

Background: The progression of pulpitis is strongly affected by the fate of dental pulp cells, with their modes of cell death determining whether inflammation resolves or leads to irreversible necrosis. Cuproptosis, a co...

Introduction and aims: Increasing evidence suggests that marginal zone B and B1 cell-specific protein (MZB1) plays crucial roles in inflammatory responses, endoplasmic reticulum (ER) stress, and cell survival, but its fu...

Introduction and Aims: Evidence suggests a relationship between oral microbiota and cardiovascular diseases (CVDs). However, the roles of specific microbiota in the pathogenesis of CVDs remain underexplored. Methods: Two...

Introduction and aims: Understanding the trend and associated factors are essential for enhancing equitable access to care, particularly given persistent disparities in healthcare utilisation across different population ...

Introduction and aims: Interleukin (IL)-38 has been identified as an anti-inflammatory cytokine; however, its specific role in temporomandibular joint (TMJ) synovial inflammation and the identity of its functional recept...

Cerium-based materials were intensively studied in last years because of their high oxygen storage capacity (OSC) associated to the reversible Ce4+ Ce3+ process and their properties closely related to the defect chemistr...

Introduction and aims: This study investigated the synergistic effect of combining 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP) and γ-methacryloxypropyl trimethoxysilane (γ-MPTS) in one primer on bonding to li...

ABSTRACT: Introduction and aims: To provide the research progress on the cGAS-STING signalling pathway and its related roles in various oral diseases. Methods: We reviewed the recent research on cGAS-STING in PubMed. Th...

Objectives: This study aimed to develop an automated deep learning (DL) system to detect and classify second molar (M2) pathologies associated with impacted third molars (ITMs) on panoramic radiographs. We sought to enha...

Introduction and Aims: Mandibular movement is a complex physiological process essential for orofacial function. Patients with disc displacement without reduction (DDWoR) exhibit significant kinematic impairments, which a...

Materias / palabras clave: Oral health; Global burden of disease; Health status indicators; Health care economics; Cost-effectiveness analysis; Quality-adjusted life years

ABSTRACT: Introduction: The links between oral health and female ageing are poorly understood, but many changes occur in the oral cavity of menopausal women that affect quality of life, and few current oral health inter...

Background and Objectives: Given the increasing use of artificial intelligence (AI) tools for dental health information, this study compared patients' perceived health information literacy for AI chatbots, measured using...