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Triple-negative breast cancer (TNBC) exhibits genomic instability and rapidly upregulates PD-L1. This study investigated whether delphinidin, the dietary anthocyanidin, could modulate both intrinsic PD-L1 signaling and S...

Bisphenol A (BPA) can combine with glycidyl methacrylate to form bisphenol A glycidyl methacrylate (Bis-GMA). Bis-GMA is an important industrial raw material and a significant component of dental resin materials. Althoug...

Alcoholic gastric ulcer is a clinically prevalent gastrointestinal disorder whose pathogenesis is closely associated with both the direct mucosal damage induced by ethanol and the subsequent inflammatory response. Isoliq...

Objective: Diabetic retinopathy (DR) is a major microvascular complication of diabetes. This study aimed to elucidate the protective effects of curcumin, a bioactive dietary compound derived from turmeric, and its underl...

Substantial efforts have been made to understand the immune response during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, in order to identify and characterize risk factors, immune mechanisms re...

Background: Renal cell carcinoma (RCC) is a highly heterogeneous malignancy lacking reliable prognostic biomarkers and effective therapeutic targets. TMEM72, a kidney-enriched protein, is dysregulated in RCC, yet its bio...

A pathological shift in bone marrow mesenchymal stem cell (BMSC) differentiation towards adipogenesis at the expense of osteogenesis is a key cellular driver of osteoporosis induced by glucocorticoids or estrogen deficie...

Background: Cardiac complications arising from diabetes mellitus manifest as structural and functional myocardial alterations independent of traditional cardiovascular risk factors. The intricate molecular underpinnings ...

Objective: To determine the optimal dosing ratio of the herbal components within compound Hemerocallis citrina Baroni (H. citrina) extract concentrate (CHEC), evaluate its antidepressant effects in zebrafish and mouse mo...

Ulcerative colitis (UC) is a type of inflammatory bowel disease. (−)-Epigallocatechin-3-gallate (EGCG) has been shown to alleviate UC; however, the underlying mechanisms by which EGCG improves UC remain unclear. Previo...

Chitooligosaccharides (COS) and fully N-acetylated chitooligosaccharides (NACOS) differ in degree of acetylation (DA), yet their anti-inflammatory activities remain unclear. This study evaluated COS and NACOS with define...

Phthalate plasticizers, especially diethyl phthalate (DEP), are linked to metabolic disorders, while their precise role and mechanism in diabetic nephropathy (DN) pathogenesis remain unclear. Here, we integrated transcri...

Objective: To investigate the role of PINK1/Parkin-mediated mitophagy in regulating synaptic remodeling of neuronal cells in depression-like behaviors induced by nonylphenol (NP). Methods: In vitro experiments: HT-22 neu...

Neurodegenerative diseases (NDs) constitute a growing global health burden driven by population aging and remain without disease-modifying therapies. Although chronic neuroinflammation and aberrant protein aggregation ar...

The Bruton nonreceptor protein-tyrosine kinase (BTK) plays a central role in B cell antigen receptor signaling. Following B cell receptor activation, the Src protein kinase Lyn and the spleen protein kinase (Syk) activat...

Background: Oral squamous cell carcinoma (OSCC) is a common oral cavity malignancy with a poor prognosis. Although chemokine-like receptor 1 (CMKLR1) has been implicated in tumor progression in several types of cancer, i...

Neurotransmitters play fundamental regulatory roles within the central nervous system (CNS), where they modulate neuronal signaling and maintain neural network homeostasis. Beyond their classical functions in the CNS, th...

Vascular and metabolic diseases, including atherosclerosis, aortic aneurysm and dissection, obesity, type 2 diabetes, and metabolic dysfunction–associated steatotic liver disease (MASLD), constitute a major global heal...