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Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic synovial inflammation, progressive cartilage destruction, and bone erosion. Although there have been significant improvements in the use of conventio...

S-palmitoylation, a key reversible lipid post-translational modification, entails the covalent conjugation of palmitic acid chains to the thiol groups of cysteine residues in proteins. This modification modulates protein...

Background: Guidelines do not recommend routine glycoprotein IIb/IIIa inhibitors (GPIs), reserving them for high thrombotic-risk or bailout cases. Most acute coronary syndrome (ACS) patients undergoing percutaneous coron...

Background and purpose: Mediastinal lymphoma patients are typically young and are at risk of long-term radiation-induced adverse events, making organ of interest (OOI) sparing a key objective of radiotherapy. This study ...

Background and purpose: Proton therapy is a promising modality for treating locally advanced non-small cell lung cancer (LA-NSCLC). However, respiratory-induced intra-fractional motion can compromise tumour coverage. Thi...

Background and purpose: Intrafraction motion degrades the efficacy of radiation therapy. We reported on the implementation of focal dose-escalated stereotactic body radiation therapy (HypoFocal-SBRT) for prostate carcino...

Objective: To develop an artificial intelligence (AI) driven plan tradeoff decision making assistant for radiation oncologists. Methods: A user interface (UI) was developed to integrate the assistant with the treatment p...

Background and purpose: Previous studies have demonstrated that mini-ridge filters (MRF) can reduce beam delivery time in pencil beam scanning (PBS) proton therapy, but the effect on plan quality has not been analyzed in...

Background and purpose: Oesophageal radiotherapy may cause side effects due to high organs of interest (OOIs) doses. While proton therapy (PT) reduces OOI dose compared to photon therapy, setup robustness settings used m...

Background and purpose: Bilateral breast or chest wall and regional nodal irradiation involves large treatment volumes adjacent to multiple critical organs. The feasibility and normal tissue sparing of proton arc therapy...

Gene therapy holds a great potential for treating a variety of human disorders by introducing foreign therapeutic genetic material into target cells using gene carriers (vectors). Most particularly, viral vectors show a ...

Resumen: La leucemia mieloide aguda es una neoplasia hematológica clonal y heterogénea, es la leucemia más frecuente en adultos, con una incidencia global cercana a 4 casos por 100 000 habitantes/año y un marcado inc...

Background: Osteoporosis has long been considered a disorder confined to bone tissue. Growing evidence now highlights its systemic origins, governed by intricate communication between multiple organs. The multi-organ-bon...