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BackgroundAs populations age rapidly, community-based care is crucial to support aging-in-place. Yet, few models successfully integrate health promotion, social engagement and care coordination at scale. Singapore’s Ac...

IntroductionWith the intensification of global population aging, mental health problems among older adults have become increasingly prominent. As an important innovative approach in smart eldercare, artificial intelligen...

BackgroundCholangiocarcinoma (CCA) carries a dismal prognosis. Beyond clinical determinants, socioeconomic deprivation may also influence outcomes. Busan, a rapidly aging metropolitan area in Korea, provides a critical s...

IntroductionAge-related declines in cognitive and motor functions show highly variable trajectories. To better understand the underlying mechanisms, we investigated multivariate associative effects between modifiable vas...

The senescence of the neuro-skeletal muscle system is typified by a gradual deterioration in muscle mass, strength, neuromuscular efficacy, and cognitive capabilities, which is further exacerbated by metabolic dysregulat...

ObjectiveThis study aimed to analyze global and regional trends in the burden of subarachnoid hemorrhage (SAH) from 1990 to 2021, focusing on incidence, prevalence, disability-adjusted life years (DALYs), and mortality, ...

BackgroundFrailty is a complex age-related clinical syndrome characterized by diminished physiological reserve and increased vulnerability to stressors. Cognitive function may be associated with frailty; however, evidenc...

BackgroundThe relationship between digital disability patterns and cognitive function among older adults remains complex. This research investigates how different patterns of digital disability were associated with cogni...

PurposeProlonged QT intervals are clinically relevant in patients with type 2 diabetes mellitus (T2DM). However, accurately detecting the Q and T points in electrocardiogram (ECG) signals remains challenging owing to the...

BackgroundHigh blood pressure (BP) is a known risk factor for dementia, but the relationships between BP and gross brain volumes are mixed and are understudied in groups who are at particularly high risk for dementia, su...

BackgroundIn the context of an aging population, nutrition plays a fundamental role. Eating habits can change in old age due to physical disorders, social isolation, and decreased appetite, leading to a decline in nutrit...

ObjectiveThe “Internet+” initiative offers new possibilities for addressing the complex health needs of aging populations. This cross-sectional study aims to investigate the demands for long-term continuous care amon...

Environmental factors such as air pollution, weather events, and ambient toxins are major contributors to human disease, with disproportionate impacts on vulnerable populations. In Puerto Rico, chronic exposure to air po...

BackgroundIn China, which has the world’s largest and one of the fastest-aging populations, multimorbidity has become a major public health challenge. Older individuals with multiple chronic conditions experience poor ...

Feeding transcends mere nourishment by integrating social and cultural factors. The foods we consume hold significant economic and social relevance within territories and are rich in bioactive compounds that confer healt...

BackgroundFrailty is significantly more prevalent in individuals with Parkinson’s disease (PD) than in general population, yet the underlying neuropathophysiological mechanisms remain poorly understood. This study aime...

BackgroundGlobal population aging is accelerating, and China faces a significant challenge with “aging before affluent.” The disabled older adults population in China is projected to reach 58 million by 2050. Early i...

ObjectivesAt the nexus of rapid digitization and demographic aging, leveraging the social potential of digital technologies to achieve active aging goals has emerged as a key concern. Drawing on the digital empowerment p...

IntroductionAgainst the backdrop of population aging and rapid digitalization in China, the new generation of older adults faces a growing paradox of digital inclusion. While digital participation can generate important ...