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IntroductionAlzheimer’s disease (AD) is strongly associated with cerebrovascular dysfunction and impaired glymphatic clearance. These dysfunctions may precede, contribute to, and interact bidirectionally with AD pathol...

IntroductionThe long-term efficacy of electroacupuncture (EA) in treating cognitive symptoms of Alzheimer’s disease (AD) remains unclear, and its time-dependent relationship requires further investigation.MethodsSixty-...

IntroductionEarly detection of Alzheimer’s disease (AD) is critical for timely intervention, particularly during the mild cognitive impairment (MCI) stage. This study aimed to develop and evaluate a multidomain speech ...

Developing effective drugs for Alzheimer’s Disease (AD) is critically limited by insufficient brain exposure. To address this, structural optimization was employed to balance physicochemical properties and enhance bloo...

Materias / palabras clave: Alzheimer’s disease; amyloid-beta; miR-32533/CREB5 pathway; neuroinflammation; oxidative stress; therapeutic strategy

IntroductionLate-life difficult-to-treat depression (LL-DTD) and dementia frequently coexist in later life, but it remains unclear whether clinical and sociodemographic characteristics, as well as medication exposure pat...

BackgroundHigh blood pressure (BP) is a known risk factor for dementia, but the relationships between BP and gross brain volumes are mixed and are understudied in groups who are at particularly high risk for dementia, su...

Background and objectivesMitochondrial dysfunction and oxidative stress are key contributors to the progression of Alzheimer’s disease (AD). Salidroside, a bioactive glycoside derived from Rhodiola rosea, exhibits neur...