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ObjectiveThe study aimed to assess the effects of resting energy expenditure (REE) on critically ill individuals requiring mechanical ventilation with different degrees of sedation.DesignA prospective self-controlled stu...

Background and aimCardiac surgery requiring cardiopulmonary bypass (CPB) is associated with a high rate of postoperative pulmonary complications (PPCs). Mechanical power (MP) represents energy per breath multiplied by re...

IntroductionProlonged immobilization in the intensive care unit (ICU) leads to ICU-acquired weakness (ICU-AW), which delays ventilator liberation and worsens outcomes. Although early mobilization is beneficial, and the P...

BackgroundBronchopulmonary dysplasia (BPD) is a common and serious complication in very preterm infants, with potential long-term adverse effects. This study aimed to analyze the perinatal and postnatal risk factors for ...

BackgroundItchy E3 ubiquitin ligase deficiency (ITCH deficiency) is a rare monogenic immune dysregulation syndrome characterized by early-onset multisystem autoimmunity and significant morbidity and mortality. Only one p...

ObjectivePrevious randomized controlled trials have shown good efficacy and safety of omadacycline in patients with infectious diseases, but relevant real-world evidence is still insufficient. This large-scale study aime...

BackgroundDelirium and poor clinical prognoses are prevalent among ICU patients, particularly those requiring mechanical ventilation. While sedation is a cornerstone of intensive care, the impact of its depth remains con...