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BackgroundSystemic sclerosis (SSc) is characterized by a complex and heterogeneous interplay between vascular dysfunction, immune activation, and progressive fibrosis. Despite advances in molecular characterization, ther...

BackgroundRecessive dystrophic epidermolysis bullosa (RDEB) is a devastating genodermatosis caused by biallelic COL7A1 mutations, where chronic inflammation drives disabling complications affecting quality of life and su...

BackgroundThe intestinal barrier is a critical interface between the host and the external environment, and growing evidence indicates that bidirectional crosstalk between the gut microbiota and the intestinal barrier is...

IntroductionThis study explores the systems-level dynamics of menu transformation in the hospitality and food service (HaFS) sector through participatory action learning (PAL) workshops with professional chefs. Framing t...

Cutaneous lymphatic vessels are essential for maintaining tissue homeostasis and coordinating immune defence, making them vital to skin health. Recent advances in molecular biology and immunology have revealed the associ...

Lung transplantation (LTx) remains limited by high immunogenicity and chronic rejection, yet the application of donor-specific blood transfusion (DSBT) in LTx has not been fully investigated. We established a murine orth...

Background and objectiveEndothelial dysfunction is a key driver of cardiovascular complications in individuals with impaired glucose tolerance (IGT), with oxidative stress and inflammation playing pivotal roles in its pa...

ObjectiveTo assess the effectiveness of a four-week trimodal prehabilitation program in enhancing the quality of life, clinical symptoms, and negative emotions of stage IV triple-negative breast cancer patients who are u...

Osteoporosis (OP), a widespread metabolic bone condition characterized by diminished bone mass and compromised microarchitecture, poses a significant global health challenge. The gut microbiota (GM) regulates bone homeos...

BackgroundThis study investigates the health status and social determinants of health among Roma and Sinti communities residing in Italy living in settlements and camps, with a particular focus on education, housing cond...

AimTo clarify the molecular mechanisms through which lobetyolin (LT) modifies the gut microbiota-bile acid axis to multitarget the regulation of hyperandrogenism, insulin resistance, chronic low-grade inflammation, and e...

ObjectiveThis systematic review and meta-analysis aims to evaluate the effects of Tai Chi Chuan on the expression of pro-inflammatory genes IL-6, IL-1β, and TNF-α—downstream of the NF-κB pathway—in adults with chr...

ObjectivesPatients with severe aplastic anemia (SAA) complicated by mucormycosis face a significantly elevated risk of mortality and present considerable therapeutic challenges. This study aimed to delineate nursing mana...

ObjectiveThis systematic review and meta-analysis synthesize preclinical evidence to evaluate the therapeutic efficacy of sinomenine in rodent models of rheumatoid arthritis, and integrate current understanding of its po...

BackgroundMind mapping has been widely used as an intervention in medical education of China’s standardized residents training (SRT) program. Our study aims to investigate the effectiveness of mind mapping compared wit...

Aging is characterized by measurable reductions in tissue repair, immune balance, and metabolic regulation. Increasing evidence suggests that these changes may arise, in part, from an insufficiency or altered quality of ...

BackgroundDedifferentiated liposarcoma (DDLPS) is a malignant mesenchymal tumor. While paraneoplastic leukemoid reaction (PLR) has been sporadically reported in DDLPS, its coexistence with severe anemia and thrombocytope...