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This study employed hepatic transcriptional changes to catalogue signature genes associated with divergent residual average daily gain (RADG) phenotypes in crossbred beef steers. A total of 108 crossbred beef steers (ave...

BackgroundSmall Nuclear Ribonucleoprotein Polypeptide A (SNRPA), an RNA-binding protein associated with HCC survival, emerges as a key regulator requiring mechanistic study.MethodsTo delineate SNRPA’s functions, we gen...

Early adversity programs induce changes that can accelerate biological aging. Using the early stress model of maternal separation (MS), we assessed oxidative, metabolic, and biochemical consequences in serum derived from...

Next generation risk assessment (NGRA) demands a fundamental transformation in how toxicological test methods are validated. Traditional validation approaches, designed for animal tests and mainly for simple in vitro met...

Aging is a complex biological process characterized by progressive functional decline and increased vulnerability to age-related diseases, particularly neurodegenerative disorders. At the biological level, aging is chara...

IntroductionVisual electrophysiology, including electroretinograms (ERG) and visual evoked potentials (VEP), provides a real-time functional assessment of retinal and post-retinal pathways, complementing structural imagi...

IntroductionAlzheimer’s disease (AD) is strongly associated with cerebrovascular dysfunction and impaired glymphatic clearance. These dysfunctions may precede, contribute to, and interact bidirectionally with AD pathol...

BackgroundBuilt environments shape navigation, attention, and motor control through continuous brain–body-environment coupling, yet architecture, rehabilitation, and clinical mobility practice still lack a shared quant...

IntroductionThe ability to remember locations of objects and make spatial decisions is critical when navigating an environment. Such tasks, however, can be difficult for individuals with certain neurological conditions, ...