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Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease around the world, with at least 40% global prevalence. Although genetic susceptibility contributes to disease risk...

Early adversity programs induce changes that can accelerate biological aging. Using the early stress model of maternal separation (MS), we assessed oxidative, metabolic, and biochemical consequences in serum derived from...

IntroductionThe emergence of multidrug-resistant bacteria, particularly vancomycin-resistant enterococci (VRE), represents a critical threat to global public health. Therefore, the development of novel therapeutic strate...

BackgroundAdjuvant immune checkpoint inhibitors (ICI) have improved survival in stage III cutaneous melanoma, yet many patients do not benefit. The tumor microenvironment is pivotal for durable responses; defining cellul...

BackgroundAccurate detection and monitoring of the oestrous cycle in West African Dwarf (WAD) goats is indispensable for reproductive management. Vaginal cytology is commonly used, but different collection methods may va...

A growing number of studies are now utilizing human organotypic brain slice cultures (OBSC), enabled by improved long-term culture protocols that support the investigation of human-specific cellular physiology. Human OBS...

BackgroundThe ubiquitin–proteasome pathway is a critical therapeutic target in malignancies, particularly multiple myeloma. The development of proteasome inhibitors (PIs) has marked a milestone in multiple myeloma ther...