Buscar recursos académicos

IntroductionMetabolism-associated fatty liver disease (MAFLD) has emerged as a severe worldwide public health burden with insufficient available clinical therapeutic strategies, which underscores the urgent demand for sa...

Micronutrients serve as critical metabolic sensors and epigenetic regulators that orchestrate cytokine production through multiple overlapping signalling cascades, transcriptional networks, and cellular metabolic states....

The senescence of the neuro-skeletal muscle system is typified by a gradual deterioration in muscle mass, strength, neuromuscular efficacy, and cognitive capabilities, which is further exacerbated by metabolic dysregulat...

BackgroundStreptococcus canis is an emerging zoonotic pathogen capable of causing infective endocarditis (IE) in animals and humans. In IE, bacterial biofilms form vegetations on heart valves, protecting microbes from a...

Circadian rhythms are essential for maintaining intervertebral disc (IDD) homeostasis and regulate cellular metabolism, mechanical responses, and therapeutic efficacy. Core clock genes, especially CLOCK and BMAL1, have c...

IntroductionThe secretome derived from Mesenchymal Stem Cells (MSCs) have received significant attention as a promising tool in regenerative medicine. This “cell-free” strategy offers a promising alternative to stem ...

Lysine lactylation (Kla) is a novel form of post-translational modification. It utilizes lactate as its core substrate. Through an enzymatic regulatory network, it mediates modifications of both histones and non-histone ...

IntroductionMatrix stiffening during idiopathic pulmonary fibrosis (IPF) creates a mechanically altered microenvironment that promotes fibroblast activation, yet the metabolic consequences of these mechanical cues remain...

STAT3 signaling is fundamental to T cells, where it underlies basic cellular processes like metabolism and apoptosis, as well as specialized processes like effector differentiation and cytokine production. However, mutat...

Dietary exposure to carcinogenic compounds generated during meat processing represents a critical yet underexplored component of the African cancer exposome. Traditional high-temperature cooking methods, including smokin...

The interplay between thyroid hormone action and the immune system has been established in physiological and pathological settings. However, their connection is complex and still not completely understood. The thyroid ho...

IntroductionBovine mastitis remains one of the most prevalent diseases in dairy cattle and is largely managed through antibiotic therapy, which contributes to antimicrobial resistance. Host-directed strategies that enhan...