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BackgroundIdentifying factors predictive of relapse in patients with alcohol use disorder (AUD) following a period of abstinence and/or treatment is essential to discover effective treatment plans for this disease. Previ...

Circadian rhythms are essential for maintaining intervertebral disc (IDD) homeostasis and regulate cellular metabolism, mechanical responses, and therapeutic efficacy. Core clock genes, especially CLOCK and BMAL1, have c...

Exercise promotes neurogenesis and enhances memory consolidation while reducing the retention of aversive memories and anxiety-like behaviors. While our previous work found that acute exercise alters neurotransmitter con...

ObjectiveTo investigate the association between night shift work and chronic kidney disease (CKD) risk and evaluate the interacting role of genetic susceptibility.MethodsThis prospective cohort study included 252,425 par...

ObjectiveDelayed sleep-wake phase disorder (DSWPD) is commonly seen in bipolar disorder (BD). However, valid screening tools for DSWPD have not been available, especially in China. Therefore, this study aimed to explore ...

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease around the world, with at least 40% global prevalence. Although genetic susceptibility contributes to disease risk...

BackgroundNumerous studies indicated inflammatory bowel disease (IBD) patients suffered from sleep disturbances. Although melatonin (MT) exerts positive effects on maintaining circadian rhythms and anti-inflammation, its...

Non-infectious uveitis encompasses a diverse array of autoimmune ocular disorders marked by the breakdown of immune tolerance and recurrent inflammatory episodes. Regulatory T cells (Tregs) are integral to the maintenanc...