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BackgroundThe association between peripheral blood immune-inflammatory markers and neurological involvement in patients with spinal tuberculosis, and to develop a predictive model for early risk assessment. Spinal tuberc...

ObjectivesTimely administration of appropriate antimicrobial therapy is critical for sepsis management, yet conventional antimicrobial susceptibility testing (AST) methods typically provide results within 24–48 hours a...

BackgroundThe research on human microbiota-associated (HMA) animal models is an important tool for studying the human microbiome and holds great potential for elucidating disease mechanisms and microbe-based therapeutic ...

Porcine circovirus-associated disease (PCVAD), caused by pathogenic porcine circovirus type 2 (PCV2), remains one of the most economically devastating diseases in the global swine industry, and the continued emergence an...

IntroductionRespiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections, while effective therapeutic options remain limited. This study investigated the antiviral efficacy, pharmacokinetics...

IntroductionThe emergence of multidrug-resistant bacteria, particularly vancomycin-resistant enterococci (VRE), represents a critical threat to global public health. Therefore, the development of novel therapeutic strate...

BackgroundThe ESKAPEE pathogens Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp. and Escherichia coli are the leading causes of nosoco...

BackgroundSevere fungal pneumonia with sepsis carries high mortality. Early and accurate prognosis is essential for improving outcomes. We developed and validated a nomogram based on immune-inflammation-nutrition indicat...

The global rise of multidrug-resistant bacteria necessitates the development of new antimicrobials and faster diagnostic tools. Conventional antimicrobial susceptibility testing is slow, relying on culture-based methods ...

Colitis-associated colorectal cancer (CAC) represents the most severe malignant complication of inflammatory bowel disease (IBD), characterized by high invasiveness, frequent recurrence, and poor prognosis. Recent studie...

IntroductionThe global prevalence of non-tuberculous mycobacterial pulmonary disease (NTM-PD) is increasing. Individuals with NTM-PD frequently develop chronic pulmonary aspergillosis, which is associated with poor clini...

Sex hormone related disorders, characterized by complex etiology and long-term health risks, pose a significant challenge to global health. Hormone-based therapies are often accompanied by adverse effects and fail to add...

Mucinous cancers are characterized by tumor gland cells secreting copious amounts of mucus that forms gel-like structures. Pseudomyxoma peritonei (PMP), a rare yet prototypical mucinous malignancy, exemplifies this patho...

IntroductionMyroides odoratimimus is a Gram-negative opportunistic pathogen primarily affecting immunocompromised individuals. However, its resistance characteristics and therapeutic response in cancer patients remain po...

BackgroundBacterial vaginosis (BV) and vulvovaginal candidiasis (VVC) are common vaginal infections; however, the existing techniques for diagnosing these infections are often subjective and inefficient. This study exami...