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IntroductionParkinson’s disease (PD) is the second most common neurodegenerative disorder. The risk of frailty is significantly higher in patients with PD than in age-matched individuals without PD. This study aimed to...

BackgroundPsychological adaptation to acquired disability, conceptualized as disability acceptance, is crucial for recovery after hypertensive intracerebral hemorrhage (HICH). However, the longitudinal course of disabili...

Plant disease diagnosis in field settings is challenged by subtle symptomology, high inter-class visual similarity, and class imbalance, making automated detection particularly difficult. While deep learning models achie...

Diabetic kidney disease (DKD) is one of the most severe complications of diabetes. Animal models of DKD play a crucial role in elucidating disease pathogenesis, exploring therapeutic strategies, and developing pharmacolo...

Pelvic inflammatory disease (PID) is a complex multifactorial infectious disorder of the female reproductive tract, associated with severe long-term sequelae including infertility, ectopic pregnancy, and chronic pelvic p...

BackgroundClimate change is increasingly recognized as a critical driver affecting the transmission and distribution of parasitic diseases. However, a comprehensive synthesis of the global research landscape in this inte...

BackgroundSystemic sclerosis (SSc) is characterized by a complex and heterogeneous interplay between vascular dysfunction, immune activation, and progressive fibrosis. Despite advances in molecular characterization, ther...

Children with epilepsy frequently experience a range of significant comorbidities beyond seizures, such as motor dysfunction, cognitive impairment, and neurodevelopmental delays. In some cases, these comorbidities contri...

A growing number of studies are now utilizing human organotypic brain slice cultures (OBSC), enabled by improved long-term culture protocols that support the investigation of human-specific cellular physiology. Human OBS...

The rapid expansion of whole-genome sequencing (WGS) has highlighted the important contribution of noncoding variants to human disease, yet their pathogenic mechanisms remain difficult to resolve. Traditional statistical...

BackgroundGlioblastoma (GBM) remains a lethal brain tumor with limited therapeutic options and near-universal recurrence. Drug repurposing offers a practical strategy, but pleiotropic compounds require systematic target ...

IntroductionMultiple sclerosis (MS) shows marked female predominance, particularly among women of childbearing age (WCBA, 15–49 years), yet their specific disease burden remains under characterized. Using Global Burden...

B cell-mediated immunity plays a crucial role in long-term humoral protection. However, dysregulation of B cell development and differentiation may lead to the persistence of autoreactive clones, contributing to autoimmu...

BackgroundSecondary hyperlipidemia is a common and serious complication in patients with clinically diagnosed depressive disorders, yet early screening tools are lacking. This study aims to develop and validate a machine...

IntroductionUnderstanding the progression of dental caries in children, characterized by transitions between distinct health states, may benefit the development of prevention and disease modeling frameworks. This systema...

BackgroundInfluenza poses a significant global public health threat, with its pandemic potential and seasonal variability presenting formidable challenges to prediction accuracy. This study leverages high-quality weekly ...

BackgroundThe research on human microbiota-associated (HMA) animal models is an important tool for studying the human microbiome and holds great potential for elucidating disease mechanisms and microbe-based therapeutic ...

BackgroundThe Zhejiang University (ZJU) index correlates with metabolic dysfunction-associated steatotic liver disease (MASLD) in Chinese cohorts, but its ethnic-specific thresholds for hepatic steatosis and fibrosis rem...

Maintaining B-cell tolerance – the elimination of self-reactive B-cells – is literally a life-long challenge because the B-cell receptor mutates to generate millions of new variants during each immune response in the...