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BackgroundBuilt environments shape navigation, attention, and motor control through continuous brain–body-environment coupling, yet architecture, rehabilitation, and clinical mobility practice still lack a shared quant...

Next generation risk assessment (NGRA) demands a fundamental transformation in how toxicological test methods are validated. Traditional validation approaches, designed for animal tests and mainly for simple in vitro met...

IntroductionSweating is essential for thermoregulation during exercise but causes variable losses of water and sodium chloride (NaCl). Field-based methods to assess these losses are limited by sampling errors and the lac...

ObjectiveThis review summarizes the current evidence on the impact of isolated antiphospholipid antibody positivity (IAAP) on pregnancy outcomes. It analyzes risk differentials across antibody subtypes, synthesizes the u...

BackgroundThe ESKAPEE pathogens Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp. and Escherichia coli are the leading causes of nosoco...

IntroductionHormone-associated cancers use steroid metabolism to grow and avoid the immune system, while traditional treatments have to deal with drug resistance and systemic toxicity.MethodsThis study is mainly divided ...

We propose that the excitability margin (ΔVmargin), defined as the difference between spike threshold and resting membrane potential, may function as a quantitative gating variable linking chronic stress, inflammatory l...

Primary human intestinal epithelial cells (IECs) require microenvironments that reproduce various in vivo cues to maintain survival, differentiation, and function in vitro. In this study, we investigated how intestinal s...