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IntroductionIn adults, Metacognitive therapy (MCT) for Generalized anxiety disorder (GAD) has demonstrated to be an effective treatment, and even superior to comparisons in randomized controlled trials. One explanation f...

IntroductionAxillary bromhidrosis is characterized by excessive sweat gland activity and foul body odor, significantly affecting patients’ psychological well-being and social interactions.MethodsThis study recruited 30...

Despite the success of HER2-targeted antibody-drug conjugates (ADCs) in common cancers, there is a lack of real-world evidence regarding their role in rare tumors where ERBB2 gene amplification by next-generation sequenc...

Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder characterized by deficient production, secretion, or action of gonadotropin-releasing hormone (GnRH), the central regulator of the reproductive axis. We r...

Cancer therapy and food preservation both face significant challenges related to stability, targeted delivery, safety, and efficiency of active compounds. Biopolymer-based nanoparticles, particularly those derived from c...

Despite major advances in lipid-lowering therapy and stent technology, a substantial proportion of patients undergoing contemporary percutaneous coronary intervention (PCI) experience recurrent major adverse cardiovascul...

BackgroundThe ubiquitin–proteasome pathway is a critical therapeutic target in malignancies, particularly multiple myeloma. The development of proteasome inhibitors (PIs) has marked a milestone in multiple myeloma ther...

ObjectiveCongenital Hypogonadotropic Hypogonadism (CHH) is a rare disease with an extremely low incidence, and the outcomes of fertility induction therapy in CHH patients exhibit significant interindividual heterogeneity...

BackgroundThere is limited understanding regarding the factors that predict recreational therapy engagement among veterans in long-term care facilities. We aimed to develop and validate machine learning models to predict...

Acute heart failure (AHF) requires immediate intervention, with diuretics central to managing volume overload. We conducted a prospective single-arm study to explore changes in diuretic and renal outcomes following initi...

Mucinous cancers are characterized by tumor gland cells secreting copious amounts of mucus that forms gel-like structures. Pseudomyxoma peritonei (PMP), a rare yet prototypical mucinous malignancy, exemplifies this patho...

Small cell lung cancer (SCLC) remains one of the most aggressive malignancies, characterized by rapid proliferation, early metastatic dissemination, and poor long-term survival despite initial sensitivity to therapy. SCL...

IntroductionEpidermolysis bullosa (EB) is a rare genetic disease with skin and mucosal fragility. Severe cases present major physical and psychological compromise, contributing to comorbidities and reducing oral health-r...