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High-altitude environments impose substantial metabolic constraints on human physiology, with oxygen limitation driving profound alterations in lipid regulation. This narrative review synthesizes current evidence on the ...

IntroductionHuman space exploration is progressing into an unprecedented era characterized by extended-duration missions, the establishment of permanent lunar bases, and planned crewed voyages to Mars. These activities i...

IntroductionIsolated maternal hypothyroxinemia (IMH), defined by low free thyroxine (FT4) with thyroid-stimulating hormone (TSH) within the reference range, is a clinically relevant thyroid phenotype in late pregnancy, w...

Primary human intestinal epithelial cells (IECs) require microenvironments that reproduce various in vivo cues to maintain survival, differentiation, and function in vitro. In this study, we investigated how intestinal s...

Background and aimsLiver sinusoidal endothelial cells (LSECs) have a key role in maintaining organismal homeostasis by scavenging blood-borne molecules and inducing specific immune tolerance to ingested antigens. The sca...

Intensive dairy sheep production systems, which represent a substantial and growing portion of the global livestock sector, present significant behavioral and welfare challenges for lambs. This review aims to summarize a...

IntroductionTalaromycosis, caused by the dimorphic fungus Talaromyces marneffei, is a significant opportunistic infection in HIV/AIDS patients in Southeast Asia. This study aimed to investigate the antifungal susceptibil...

IntroductionMatrix stiffening during idiopathic pulmonary fibrosis (IPF) creates a mechanically altered microenvironment that promotes fibroblast activation, yet the metabolic consequences of these mechanical cues remain...

IntroductionAquatic light environments are increasingly altered by human activity, yet the endocrine and molecular mechanisms enabling fish to cope with extreme photoperiods remain poorly understood. This study investiga...

BackgroundStreptococcus canis is an emerging zoonotic pathogen capable of causing infective endocarditis (IE) in animals and humans. In IE, bacterial biofilms form vegetations on heart valves, protecting microbes from a...