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BackgroundThe methylation status of cell-free DNA (cfDNA) shows promise for the clinical detection of cervical cancer and its precursors; however, its measurement in liquid biopsies is hindered by low cfDNA yields and te...

BackgroundAlterations in ribosomal DNA copy number (rDNA-CN) and global DNA methylation have been associated with genomic instability and various diseases. However, their relevance in myocardial infarction (MI) has not b...

Protein arginine methyltransferase 3 (PRMT3) is a type I arginine methyltransferase that catalyzes asymmetric dimethylation of arginine residues on diverse substrate proteins. Initially characterized as a regulator of ri...

Autoimmune rheumatic diseases (ARDs), often characterized by pain, constitute a diverse group of autoimmune conditions involving inflammation-mediated injuries to bones, joints, surrounding connective tissues, and occasi...

DNA methylation is an essential epigenetic modification. However, the dynamics of DNA methylation during cabbage bolting remain poorly understood. To investigate changes in DNA methylation during cabbage bolting, we perf...

Sepsis-induced cardiomyopathy (SICM) develops in up to 60% of patients with sepsis, substantially increases mortality, and currently lacks specific pharmacotherapy. N6-methyladenosine (m6A), the most prevalent internal m...

The treatment of paediatric low-grade gliomas has been previously controversial as to whether upfront surgery or a conservative approach should be utilised, with a recent paradigm shift favouring biopsy or resection, if ...

BackgroundGranular cell astrocytoma (GCA) is a rare, morphologically distinct variant of IDH-wildtype glioblastoma that can appear deceptively low-grade yet behave aggressively. Its molecular features remain poorly defin...

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease around the world, with at least 40% global prevalence. Although genetic susceptibility contributes to disease risk...

Nasopharyngeal carcinoma (NPC) is a metastasis-prone malignancy that is highly prevalent in endemic regions. Epigenetic dysregulation, including aberrant DNA/RNA/protein methylation, histone modifications, and non-coding...

Transposable elements (TEs) make up almost half of the human genome and are among its most densely methylated regions. Their epigenetic silencing is crucial for genomic stability and immune homeostasis, and accumulating ...

Glioblastoma is the most common and aggressive primary brain tumor in adults that fails to meet survival endpoint criteria in current immunotherapy Phase III clinical trials. As a small subset of immunotherapy-responsive...

IntroductionC5orf46 is a recently discovered tumor-progression-related gene whose function in most cancers is still unknown, especially its potential role in regulating the tumor microenvironment (TME). The aim of the st...

BackgroundOral submucosal fibrosis (OSF) is a chronic and progressive disorder, caused by chewing areca nuts, affecting the oral cavity and oropharynx. OSF is characterized by severe symptoms like severe burning sensatio...

Post-translational modifications (PTMs) play pivotal roles in ovarian cancer pathogenesis, with poly(ADP-ribosyl)ation (PARylation) serving as a key regulator of DNA repair, immune evasion, and therapeutic resistance. Be...

Post-transplant lymphoproliferative disorders (PTLD) represent a heterogeneous group of complications with rising complexity, particularly as EBV-negative forms are increasingly recognized in adult recipients. While earl...

Natural antisense transcripts (NATs) from eukaryotic genes, known as long non-coding RNAs (lncRNAs), are long transcripts that do not encode proteins. NATs play diverse functional roles in regulating the transcription, s...