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10 resultados encontrados.

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Dose-dependent effects of pomegranate peel extract on modulating ruminal fermentation, methane emission, nutrient digestibility and productive values in camels: an in vitro and in silico integrations
Artículo
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Dose-dependent effects of pomegranate peel extract on modulating ruminal fermentation, methane emission, nutrient digestibility and productive values in camels: an in vitro and in silico integrations
Abdullah Sheikh et al · Frontiers Media S.A · 2026 · ISSN 2297-1769
IntroductionSustainable management of bioactive-rich byproducts, including pomegranate peels, is crucial to support the rise of environmentally resilient intensive camel farming. The objective of this study was to invest...
LCC TENDOlZldGVyaW5hcnkgbWVkaWNpbmU~Idioma eng
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GC–MS metabolomic profiling and PPARγ-targeted in silico approaches for identifying a potential anti-diabetic compound from traditional rice varieties
Artículo
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GC–MS metabolomic profiling and PPARγ-targeted in silico approaches for identifying a potential anti-diabetic compound from traditional rice varieties
Saranya Nallusamy et al · Frontiers Media S.A · 2026 · ISSN 2296-861X
Traditional rice varieties are known to exhibit anti-oxidant, anti-inflammatory, anti-diabetic, anti-cancer, and cardioprotective properties due to their nutritional profile and diverse phytochemical composition. The pre...
LCC LCC:Nutrition. Foods and food supplyIdioma eng
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Integrated pharmacology and experimental validation reveals potential multiple mechanisms of the neutrophil elastase inhibitor sivelestat in attenuating myocarditis
Artículo
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Integrated pharmacology and experimental validation reveals potential multiple mechanisms of the neutrophil elastase inhibitor sivelestat in attenuating myocarditis
Ruguo Ren et al · Frontiers Media S.A · 2026 · ISSN 1663-9812
BackgroundMyocarditis is an inflammatory cardiomyopathy characterized by high level of inflammatory cell infiltration and progressive cardiac dysfunction. The underlying pathogenesis involves direct pathogen damage and i...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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Plasma proteome-wide Mendelian randomization reveals multi-ancestry drug targets for gastric cancer
Artículo
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Plasma proteome-wide Mendelian randomization reveals multi-ancestry drug targets for gastric cancer
Peng Zhi et al · Frontiers Media S.A · 2026 · ISSN 2234-943X
BackgroundGastric cancer (GC) exhibits marked epidemiological differences between European (EUR) and East Asian (EAS) populations, with significantly higher incidence rates in EAS. Circulating proteins represent promisin...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Thermosonication of traditional poppy vinegar: modulation of biomolecules, phenolic profile, and antidiabetic potential in a functional fermented food
Artículo
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Thermosonication of traditional poppy vinegar: modulation of biomolecules, phenolic profile, and antidiabetic potential in a functional fermented food
Meryem Akhan et al · Frontiers Media S.A · 2026 · ISSN 2296-861X
Traditional poppy vinegar is a functional fermented food matrix enriched with diverse biomolecules that may contribute to metabolic health. In this study, the effects of thermosonication on the biomolecular profile, anti...
LCC LCC:Nutrition. Foods and food supplyIdioma eng
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Transcriptomics-guided discovery of Interleukin-6 modulators from Bacillus subtilis metabolites in type 2 diabetes mellitus
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Transcriptomics-guided discovery of Interleukin-6 modulators from Bacillus subtilis metabolites in type 2 diabetes mellitus
Tarsha Muthukumar et al · Frontiers Media S.A · 2026 · ISSN 2673-7647
Type 2 diabetes mellitus (T2DM) is characterized by chronic metabolic dysfunction and low-grade inflammation. This study aimed to identify inflammation-associated molecular targets in T2DM and to computationally evaluate...
LCC TENDOkNvbXB1dGVyIGFwcGxpY2F0aW9ucyB0byBtZWRpY2luZS4gTWVkaWNhbCBpbmZvcm1hdGljcw~~Idioma eng
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Delphinidin-3-O-glucoside attenuates neonatal hypoxic-ischemic encephalopathy in a neonatal mouse model by reprogramming microglial polarization
Artículo
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Delphinidin-3-O-glucoside attenuates neonatal hypoxic-ischemic encephalopathy in a neonatal mouse model by reprogramming microglial polarization
Jiacan Xu et al · Frontiers Media S.A · 2026 · ISSN 1663-9812
BackgroundCerebral ischemic injury includes ischemic stroke in adults and hypoxic-ischemic encephalopathy (HIE) in newborns. Delphinidin-3-O-glucoside (Dp3G) is a bioactive anthocyanin abundant in vibrantly colored plant...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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Dual-targeting phytochemicals Ergosterol and Quercetagetin implicate steroid metabolism–associated pathways in lung and liver cancer models
Artículo
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Dual-targeting phytochemicals Ergosterol and Quercetagetin implicate steroid metabolism–associated pathways in lung and liver cancer models
Yujiao Chen et al · Frontiers Media S.A · 2026 · ISSN 1663-9812
IntroductionHormone-associated cancers use steroid metabolism to grow and avoid the immune system, while traditional treatments have to deal with drug resistance and systemic toxicity.MethodsThis study is mainly divided ...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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HSF1 modulates lipid metabolism and ferroptosis in sarcopenia: a novel diagnostic biomarker and therapeutic target
Artículo
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HSF1 modulates lipid metabolism and ferroptosis in sarcopenia: a novel diagnostic biomarker and therapeutic target
Dalu Cheng et al · Frontiers Media S.A · 2026 · ISSN 2296-889X
BackgroundSarcopenia, an age-correlated decline in skeletal muscle mass and function, has been increasingly linked to ferroptosis, which is an iron-dependent form of regulated cell death driven by lipid peroxidation. Nev...
LCC LCC:Biology (General)Idioma eng
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Integrative analysis of 16S rRNA sequencing and network pharmacology suggests protective effects of Sihuang Zhili Granules against APEC O78 challenge through gut homeostasis-related changes
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Integrative analysis of 16S rRNA sequencing and network pharmacology suggests protective effects of Sihuang Zhili Granules against APEC O78 challenge through gut homeostasis-related changes
Zikai Guo et al · Frontiers Media S.A · 2026 · ISSN 2297-1769
IntroductionAvian pathogenic Escherichia coli (APEC) infection poses a serious threat to the poultry industry and is increasingly difficult to control because of antimicrobial resistance.MethodsThis study combined microb...
LCC TENDOlZldGVyaW5hcnkgbWVkaWNpbmU~Idioma eng
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