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ObjectiveObstructive sleep apnea (OSA) is increasingly recognized for its association with significant morbidity and mortality. Despite advances in understanding OSA’s impacts, the role of systemic inflammation in this...

BackgroundUlceration is a common complication of infantile hemangioma, and its management poses unique difficulties when the lesion is located in high-risk areas like the scrotum. This case report details the successful ...

BackgroundThe systemic immune-inflammation index (SII) has emerged as a widely studied inflammatory biomarker reflecting the balance between host inflammatory and immune status, although evidence in lung cancer patients ...

ObjectiveSystemic inflammatory response plays a key role in the pathogenesis of endometriosis. This study aimed to investigate the association between the aggregate index of systemic inflammation (AISI), defined as neutr...

ObjectiveSarcopenia is a progressive and complex disorder associated with higher morbidity and mortality, which significantly increases the financial burden and medical costs. This study aims to investigate the relations...

BackgroundRecessive dystrophic epidermolysis bullosa (RDEB) is a devastating genodermatosis caused by biallelic COL7A1 mutations, where chronic inflammation drives disabling complications affecting quality of life and su...

BackgroundThe prevalence of female sexual dysfunction (FSD) among women with systemic lupus erythematosus (SLE) is inconsistent, and whether SLE is a risk factor for FSD among women remains controversial. Therefore, this...

BackgroundTransarterial chemoembolization (TACE) is a standard treatment for intermediate-stage hepatocellular carcinoma (HCC), but its efficacy varies due to patient heterogeneity. Combining TACE with systemic therapies...

Early adversity programs induce changes that can accelerate biological aging. Using the early stress model of maternal separation (MS), we assessed oxidative, metabolic, and biochemical consequences in serum derived from...

IntroductionWe aimed to evaluate the long-term effects of systemic ceftiofur (CEF) and ampicillin (AMP) on the abundance and duration of fecal shedding of resistant Gram-negative (GN) bacteria from healthy dairy cows, as...

Early-life vaccinations often yield short-lived antibody (Ab) responses due to limited germinal center (GC) reaction and plasma cell (PC) survival. The aim of the study was to assess how vaccine delivery routes (homologo...

BackgroundImmune checkpoint inhibitors (ICIs) have transformed treatment of locally advanced gastric cancer (LAGC), yet response heterogeneity and immune-related adverse events (irAEs) remain major challenges. Systemic i...

ObjectiveTo identify sleep-disordered breathing phenotypes in older adults with depressive disorder and obstructive sleep apnea-hypopnea syndrome (OSAHS) and to evaluate their associations with systemic inflammation.Meth...

Autoimmune rheumatic diseases (ARDs), often characterized by pain, constitute a diverse group of autoimmune conditions involving inflammation-mediated injuries to bones, joints, surrounding connective tissues, and occasi...

Severe gingival inflammation, which is uncommon in pediatric patients, often indicates underlying systemic conditions. Leukemia, autoimmune diseases, and allergic symptoms can cause gingivitis owing to systemic inflammat...

ObjectiveThe present Bayesian network meta-analysis (NMA) aims to evaluate and compare the efficacy of aerobic training (AT), resistance training (RT), high-intensity interval training (HIIT), and combined training (CT) ...

BackgroundBalancing pulmonary and systemic blood flow remains one of the most critical challenges in the management of high-risk neonates with ductal-dependent circulation, particularly in the presence of low birth weigh...

IntroductionPolyarteritis nodosa (PAN) is a rare systemic necrotizing vasculitis affecting medium-sized vessels. While peripheral neuropathy occurs in 50–75% of patients, cranial nerve involvement is exceptionally rare...