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Abstract Alzheimer’s disease, a progressive neurodegenerative disorder, presents a growing global health challenge due to its increasing prevalence and lack of accessible early diagnostic methods. Even though it has en...

Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-β and tau pathology, neuroinflammation, oxidative stress, and cognitive decline. Emerging evidence indicates that ...

Abstract Background Alzheimer’s disease (AD) carries a high societal burden inequitably distributed across demographic groups. Using real-world electronic health record (EHR) data with accurate population identificatio...

Abstract Limited studies have evaluated the influence of redox-related metals on the Alzheimer´s brain. We determined 15 metals in 241 human brain samples obtained from five biobanks. We examined the levels of metals in...

Abstract High-throughput analysis of EEG data has significantly contributed to understanding neural dynamics in Alzheimer’s disease diagnosis. However, the complexity and high dimensionality of EEG signals pose challen...

Abstract Neuroinflammation is a pathological feature of neurodegenerative diseases like Alzheimer’s disease and ALS. Cytoplasmic dsRNA (cdsRNA) triggers a type-I interferon response in human neural cells, leading to th...

Abstract Background Naringenin has shown attractive neuroprotective effects; however, it is characterized by low oral bioavailability. Naringenin-loaded nanoparticles (Nar-NPs) were prepared for enhanced delivery, and ...

Abstract Aging is a primary risk factor for chronic diseases, with cellular senescence as an effective target to delay, prevent or alleviate age-related disorders. Here we report in vitro screening outputs from a natural...