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Abstract In bronchial asthma, M2 macrophage polarization and PI3K/Akt/mTOR pathway activation are critically implicated in airway inflammation and remodeling. This study employed an OVA-induced asthmatic mouse model to e...

Abstract The heart-brain axis is a significant contributor to morbidity and mortality following ischemic injury. Pathological and psychological changes in the heart can lead to anxiety, cognitive impairment, and brain in...

Abstract Abdominal aortic aneurysm (AAA) is a common cardiovascular disease resulting in high mortality rate due to rupture. Intraluminal thrombus (ILT) is involved in AAA progression via both biomechanically protective ...

Abstract Tumor-associated macrophages can either promote or suppress cancer, but therapeutic targeting remains challenging because we lack a predictive framework for macrophage function. The prevailing M1/M2 paradigm ove...

Abstract Pancreatic ductal adenocarcinoma remains one of the most formidable challenges in oncology, with limited treatment options and a poor prognosis. Understanding the key pathways affecting cancer progression is cru...

Abstract The sympathetic nervous system (SNS) plays a critical role in regulating inflammatory responses after myocardial infarction (MI). We aimed to investigate whether modulation of the SNS through renal denervation (...

Abstract The aim of this study was to examine the dynamic changes in monocyte/macrophage- and dendritic cell (DC)-related immune activation in people with HIV (PWH) before switching to long-acting (LA) injectable caboteg...