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The aim of this study was to formulate gliclazide loaded controlled release microspheres. Microspheres were prepared by quasi emulsion solvent diffusion technique using eudragit RLPO, eudragit RSPO and with their various...

In the present study matrix and multilayered matrix tablets of diltiazem HCl were formulated by using guar gum as matrix core component and cellulose derivative, Sodium Carboxy Methyl Cellulose (SCMC) as barrier layers. ...

The prolonged residence of drug formulation in the nasal cavity is of utmost importance for intranasal drug delivery. The objective of the present investigation was to develop a mucoadhesive in situ gel with reduced nasa...

The purpose of this study was to improve the meloxicam dissolution rate through its formulation into liquisolid compacts and then to evaluate the in vitro and in vivo performance of the prepared liquisolid compacts. Di...

The purpose of this work was to design and evaluate a novel vaginal delivery system for the local treatment of vaginal candidiasis. Bioadhesive vaginal films of metronidazole that could be retained in the vagina for prol...

The purpose of this study was to design a novel vaginal delivery system composed of metronidazole microspheres dispersed within a bioadhesive gel. Microspheres were prepared by solvent evaporation method using Eudragit...

A new reversible thermosensitive drug delivery system was designed and prepared by using chitosan and glycerophosphate with or without poly (ethylene glycol) and used as an a carrier for the Miconazole nitrate, an antifu...

The objective of the present study was to develop an oral timed-released press-coated tablet containing theophylline as a model drug. A D-optimal design of experiment was employed to systematically study the effect of te...

Lipid-based nanocarriers were prepared by hot solvent diffusion technique. Tristearin (TS) and/or castor oil were employed as oily phase, and Lutrol F68® or Solutol HS15® and lecithin were employed as surfactant and co...

A simple, efficient and reliable capillary zone electrophoresis method with diode array detection was developed and validated for the simultaneous determination of olmesartan medoxomil and amlodipine besylate in their bi...

The aim of this study was to evaluate the in vivo behavior of matrix tablets formulated with ketoprofen as a model drug after oral administrations in healthy Malaysian male volunteers and to compare its rate and extent o...

The objective of the present investigation was to investigate the effects of selected drugs (captopril and celecoxib) properties on different parameters drug entrapment, in vitro drug release, release pattern, in vitro d...

The aim of this study was to analyze the effects of formulations containing DMAE pidolate and DMAE acetoamidobenzoate on the skin. Four areas of five swines were submitted to following treatments during 15 days: C (Contr...

The purpose of development oral fast disintegrating drug delivery is not only to give fast relief but also to overcome difficulty in swallowing tablets and capsules, resulting in non-compliance and ineffective therapy. T...

A simple, specific, sensitive and validated RP-HPLC method for the simultaneous estimation of amlodipine (AMB) and valsartan (VAL) in marketed tablet formulation was developed. The analysis was carried out on a phenomene...

The presence of rice bran or soybean oil at different concentrations (3 and 5 %) in gel-creams containing benzophenone-3 (BZ-3) was evaluated. Gel-creams were prepared with Carbopol Ultrez® (polymer) at 0.5 % (w/w). T...

En este trabajo se describe el desarrollo de una formulación de tabletas revestidas de Azitromicina dihidrato 500 mg. El método de fabricación empleado fue la vía húmeda convencional, tomando en consideración las c...

The lack of pharmaceutical formulations proper for children favors the manipulation of extemporaneous oral preparations by hospital pharmacies. The study aimed to identify the medications reformulated by the pharmacy of ...

Actualmente, el meprobamato no es un fármaco de amplio espectro comercial. Con el objetivo de obtener una formulación farmacéutica óptima para este fármaco u otros más competitivos, la metodología de diseños expe...

A new spectrophotometric method was developed for the determination of captopril (n donor) through charge transfer complex formation with p-chloranil (π acceptor). The different experimental parameters that affect the a...

O objetivo deste estudo foi avaliar in vitro o efeito do óleo essencial de Thymus vulgaris (tomilho) puro ou incorporado em uma formulação farmacêutica de uso oral (enxaguatório bucal), frente ao Streptococcus mut...

O Formulário Nacional (FN) é o código oficial brasileiro onde estão inscritas formulações farmacêuticas oficiais, e tem como objetivo a padronização dos medicamentos e cosméticos nele inscritos, com o intuito d...

Diferentes ensaios de controle de qualidade foram realizados com cápsulas manipuladas de piroxicam, denominadas formulações A, B e C, as quais foram adquiridas no município de Florianópolis, SC, Brasil. As três for...

The self-microemulsifying drug delivery system (SMEDDS) was employed to improve the bioavailability of sulpiride, a drug which is poorly soluble. The mean droplet size and emulsification time of the test formulation us...