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The purpose of the present study was to prepare spherical agglomerates (SA) of piroxicam by solvent change method. Crystallization medium used for spherical agglomerates of piroxicam consisted of DMF:water and chloroform...

Cabergoline (CAB) is a synthetic ergoline dopamine agonist with high affinity to D2 receptors, thus used for the treatment of Parkinson's patients and hyperprolactinemia disorders. In this study, simple, fast, reliable a...

As ormosílicas (sílicas organicamente modificadas) são materiais de impressão molecular (MIS) que têm surgido como sorventes mais seletivos para a extração em fase sólida (SPE). Nesta pesquisa foi avaliado o de...

The objective of this paper was to develop a high performance liquid chromatography with diode array detection both for chromatographic fingerprint and simultaneous determination of twelve analytes of Shuang-Huang-Lian (...

La microscopía electrónica de transmisión (MET) puede ser usada para el diagnóstico de enfermedades de origen microbiana, aunque su principal aplicación es en investigación. La MET provee detalles ultraestructurale...

A simple and sensitive LC-ESI-MS method for determination of norvancomycin in plasma was developed and validated over the concentration range of 20-2,000 ng/mL. After addition of vancomycin as internal standard (IS), p...

A sensitive and selective liquid chromatography tandem mass spectrometry (LC-MS/MS) method for determination of diphenhydramine hydrochloride in rabbit plasma was developed and validated. After addition of triazolam as i...

A sensitive and selective liquid chromatography-mass spectrometry (LC–MS) method for determination of esomeprazole in rabbit plasma was developed and validated. After addition of midazolam as internal standard (IS), pr...

A sensitive and selective liquid chromatography-mass spectrometry (LC-MS) method for determination of ibudilast in rabbit plasma was developed and validated. After addition of estazolam as internal standard (IS), protein...

Nowadays there are no official in vitro methods to determine TiO2, ZnO or other inorganic elements in sunscreen cosmetics. The objective of this work is to determine the concentration of several inorganic elements in sun...

A sensitive and simple liquid chromatography/electrospray mass spectrometry (LC-ESI-MS) method for determination of ketamine in rabbit plasma using one-step protein precipitation was developed and validated. After additi...

A sensitive and selective liquid chromatography tandem mass spectrometry (LC–MS/MS) method for determination of meropenem in rabbit plasma was developed. After addition of triazolam as internal standard (IS), protein p...

A sensitive and simple liquid chromatography/electrospray mass spectrometry (LC-ESI-MS) method for determination of ramosetron in rat plasma using one-step protein precipitation was developed and validated. After additio...

A sensitive and selective liquid chromatography/electrospray mass spectrometry (LC-ESIMS) method for determination of tetramethylpyrazine in rat plasma was developed. After addition of phenacetin as internal standard, ...

A sensitive and selective liquid chromatography-tandem mass spectrometry method (LC-MS/MS) for the determination of tolbutamide in rabbit plasma was developed and validated over the concentration range of 4-1000 ng mL-...

A sensitive and selective liquid chromatography/electrospray mass spectrometry (LC-ESIMS) method for determination of troxerutin in rabbit plasma was developed. After addition of paeoniflorin as internal standard (IS), p...

A sensitive and simple liquid chromatography/electrospray mass spectrometry (LC-ESI-MS) method for determination of dapoxetine in rat plasma using one-step protein precipitation was developed and validated. After additio...

A sensitive and simple liquid chromatography/electrospray mass spectrometry (LC-ESI-MS) method for determination of tramadol in rat plasma using one-step protein precipitation was developed. After addition of ketamine as...

A sensitive and simple liquid chromatography/electrospray mass spectrometry (LC-ESI-MS) method for determination of torsemide in rabbit plasma using one-step protein precipitation was developed and validated. After addit...

This paper describes a rapid (2.0 min) and sensitive (LLOQ 5 ng/mL) analytical method for the quantitation of hydrochlorothiazide (HCTZ) in human plasma. The method is based on High-performance Liquid chromatography-tand...

To develop a high performance liquid chromatography method for the simultaneous determination of cortisone and cortisol in rat serum and apply it for pharmacokinetics. After addition of pirfenidone as internal standard (...

O interesse na aplicação de sistemas nanoestrurados como veículo de preparações farmacêuticas se deve a capacidade destes de solubilizar substâncias hidrofílicas e lipofílicas. Com isto, têm sido utilizados vis...

O Formulário Nacional (FN) é o código oficial brasileiro onde estão inscritas formulações farmacêuticas oficiais, e tem como objetivo a padronização dos medicamentos e cosméticos nele inscritos, com o intuito d...

En los últimos años hay un notable aumento de la demanda de fármacos con extractos vegetales estandarizados. Muchos de ellos, con indicación de actividad colagoga y colerética, contienen extracto de alcachofa. Con e...